The clinical effectiveness and cost-effectiveness of central venous catheters treated with anti-infective agents in preventing bloodstream infections: a systematic review and economic evaluation

Health Technology Assessment : HTA
Juliet C HockenhullRumona C Dickson

Abstract

To assess the clinical effectiveness and cost-effectiveness of central venous catheters (CVCs) treated with anti-infective agents in preventing catheter-related bloodstream infection (CRBSI). Major electronic databases were searched from 1985 to August 2005. The systematic clinical and economic reviews were conducted according to accepted procedures. Only full economic evaluations (synthesis of costs and benefits) comparing the use of anti-infective central venous catheters (AI-CVCs) with untreated CVCs or other treated catheters were selected for inclusion in the economic review. A total of 32 trials met the clinical inclusion criteria. Seven different types of AI-CVC were identified, with the most frequently tested being chlorhexidine and silver sulfadiazine (CHSS) (externally treated), CHSS (externally and internally treated) and minocycline rifampicin (internally and externally treated). In general, the trials were of a poor quality in terms of reported methodology, microbiological relevance and control of confounding variables. The pooled result suggests a statistically significant advantage for AI-CVCs in comparison to standard catheters in reducing CRBSI [odds ratio (OR) 0.45, 95% confidence interval (CI) 0.34 to 0.60, 2...Continue Reading

Citations

Sep 12, 2013·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Stefano FagiuoliPierluigi Toniutto
Mar 25, 2014·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Roberto BiffiIsidoro Di Carlo
Oct 4, 2014·American Journal of Infection Control·Leonardo LorenteMaría L Mora
Dec 22, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·L LorenteA Sierra
Mar 4, 2014·American Journal of Infection Control·Leonardo LorenteMaría L Mora
Dec 18, 2013·The Journal of Hospital Infection·H P Loveday UK Department of Health
Nov 30, 2011·Critical Care Clinics·Marya D Zilberberg, Andrew F Shorr
Sep 3, 2016·Journal of Arrhythmia·Yusuke KondoJoerg O Schwab
May 11, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Alessandro Pontes-ArrudaCatherine Mercaldi
Feb 4, 2014·Evidence-based Child Health : a Cochrane Review Journal·Clare van MiertLeanne Jones
Sep 3, 2016·JPEN. Journal of Parenteral and Enteral Nutrition·Manpreet S MundiM Molly McMahon
May 7, 2016·World Journal of Critical Care Medicine·Leonardo Lorente
Sep 28, 2015·The Cochrane Database of Systematic Reviews·Munisha BalainWilliam McGuire
Mar 17, 2016·The Cochrane Database of Systematic Reviews·Nai Ming LaiSanjay Saint
Apr 30, 2016·British Journal of Nursing : BJN·Nancy Moureau, Vineet Chopra
Apr 20, 2012·The Cochrane Database of Systematic Reviews·Clare van MiertLeanne Jones
Dec 22, 2010·Surgical Infections·Jill R Cherry-BukowiecLena M Napolitano
Sep 2, 2016·Journal of Infection Prevention·Praveen ThokalaTony Whitehouse
Jul 19, 2013·Seminars in Dialysis·S Daisy Kosa, Charmaine E Lok
Aug 4, 2020·World Journal of Gastroenterology : WJG·Ke-Cheng ZhangUNKNOWN Chinese Research Hospital Association Digestive Tumor Committee; Chinese Association of Upper Gastrointestinal Surgeons; Chi
Oct 15, 2010·Pacing and Clinical Electrophysiology : PACE·Heather L BloomUNKNOWN COoperative Multicenter study Monitoring a CIED ANtimicrobial Device Investigators
May 31, 2019·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Ivo KrikavaPavel Sevcik
Aug 21, 2018·Applied Health Economics and Health Policy·Tom MacmillanAnastasia Chalkidou
Aug 21, 2013·Biomaterials·Davide CampocciaCarla Renata Arciola
Jun 24, 2021·IJC Heart & Vasculature·Mariana AlbanoRobin Patel
Jul 19, 2021·Alimentary Pharmacology & Therapeutics·Marcel Kjaersgaard EriksenChristian Lodberg Hvas

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