PMID: 20646417Jul 22, 2010Paper

The clinical efficacy and safety of itraconazole injection in treatment of invasive fungal infection in intensive care unit

Zhonghua nei ke za zhi
Collaborative Research Group of Itraconazole in Intensive Care Unit

Abstract

To investigate the efficacy and safety of itraconazole injection for the treatment of invasive fungal infection (IFI) in ICU. In this multicenter, prospective open-label study, ICU patients who had met the IFI inclusion criteria were enrolled. Itraconazole intravenous injection was administered 200 mg twice daily. Clinical efficacy and adverse events were recorded. A total of 495 patients from 33 centers were enrolled with 62.02% clinical diagnosis, 30.69% probable diagnosis and 7.29% confirmed diagnosis. The infection sites were mostly from the lung (86.51%) and the urinary tract and bloodstream stood for the second place (4.07%). Of all the infections, 82.66% were candida whereas 14.63% were aspergillus. Broad-spectrum antibiotics usage, severe illness and long-term hospitalization were the most common risk factors for IFI (70.47%, 69.45% and 62.12% respectively). The clinical cure rate was 53.91% at day 7 and increased to 78.53% at the end of treatment. Total fungal clearance increased from 58.62% at day 7 to 86.27% at the end of treatment. The rate of total adverse event was 8.48% with 6.87% drug-related. Itraconazole injection was an effective and safe drug for the treatment of IFI in ICU.

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