The Clinical Efficacy and Safety of the Sahastara Remedy versus Diclofenac in the Treatment of Osteoarthritis of the Knee: A Double-Blind, Randomized, and Controlled Trial

Evidence-based Complementary and Alternative Medicine : ECAM
Piya PinsornsakArunporn Itharat

Abstract

Introduction. The Sahastara (SHT) remedy is a Thai traditional medicine that has been acknowledged in the Thai National List of Essential Medicine and has been used as an alternative medicine to treat knee osteoarthritis. Although SHT remedies have been used in Thai traditional medical practices for a long period of time, there are few reports on their clinical trials. Aim of the Study. To investigate the clinical efficacy and safety of the SHT remedy in treating OA of the knee when compared to diclofenac. Methods. A phase 2, double-blind, randomized, and controlled trial study with a purpose to determine the clinical efficacy and safety of SHT in comparison with diclofenac for the treatment of knee osteoarthritis. Sixty-six patients, ages between 45 and 80 years of age, were randomly allocated into 2 groups. The SHT group received 1,000 mg of SHT powdered capsules 3 times per day, orally before meals, while another group received 25 mg of diclofenac sodium capsules 3 times a day, orally after meals for 28 days. All patients were followed up at 14 and 28 days for the evaluation of the efficacy and safety by using clinical examinations, blood tests, a visual analogue scale (VAS) for pain, and the 100-meter walktime test. Improve...Continue Reading

References

Jan 29, 2009·The American Journal of Gastroenterology·Loren LaineChristoper P Cannon
Jul 11, 2013·International Immunopharmacology·Xiaozhou YingHua Zi Xu

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Citations

Mar 24, 2018·International Journal of Hepatology·Pajaree SriutthaUnchalee Permsuwan
May 7, 2020·BMC Complementary Medicine and Therapies·Sumalee PanthongArunporn Itharat
Feb 4, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Narin KakatumArunporn Itharat
Apr 3, 2021·Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders·Christopher VannabouathongMohit Bhandari

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