The Clinical Efficacy of Pollen Extract and Vitamins on Chronic Prostatitis/Chronic Pelvic Pain Syndrome Is Linked to a Decrease in the Pro-Inflammatory Cytokine Interleukin-8

The World Journal of Men's Health
Tommaso CaiGianni Malossini

Abstract

We aim to evaluate the efficacy of pollen extract in association with vitamins in patients affected by chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and to evaluate the level of the pro-inflammatory mediators interleukin (IL)-6, IL-8, and IL-10. Patients diagnosed with CP/CPPS between January and December 2015 were enrolled in this study. Participants were randomly assigned to receive oral capsules of pollen extract and vitamins (group A) or bromelain (group B) for 3 months. At the enrolment time and 3 months after enrolment, all patients completed questionnaires (the National Institutes of Health Chronic Prostatitis Symptom Index [NIH-CPSI] and the Short Form-36 and underwent urological examinations and microbiological evaluation. Levels of IL-6, IL-8, and IL-10 were evaluated in seminal plasma. Sixty-five male patients (mean age of 32.7±4.7 years) were analysed (group A, n=32; group B, n=33). At the follow-up examination, 24 of the 32 patients in group A showed a significant reduction in the NIH-CPSI total score compared with 8 of the 33 patients in the bromelain group (p<0.001). Moreover, the mean level of IL-8 was significantly lower in the pollen extract and vitamins group when compared with the bromelain grou...Continue Reading

References

Jun 1, 2005·European Urology·Gianluca GiubileiRiccardo Bartoletti
Mar 1, 2008·BJU International·J Curtis Nickel
Jul 30, 2011·The Urologic Clinics of North America·Florian M E WagenlehnerWolfgang Weidner
Jun 7, 2013·World Journal of Urology·Amin S Herati, Robert Miles Moldwin
Oct 7, 2016·Archivio italiano di urologia, andrologia : organo ufficiale [di] Società italiana di ecografia urologica e nefrologica·Tommaso CaiGianni Malossini

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Citations

May 13, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marcello LocatelliGiustino Orlando
Oct 7, 2019·The Cochrane Database of Systematic Reviews·Juan Va FrancoValeria Vietto
Apr 8, 2020·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Junjun LiDegui Chang
May 6, 2019·International Urology and Nephrology·Min HuXiaohui Zhou
Aug 4, 2021·International Journal of Urology : Official Journal of the Japanese Urological Association·Hiroyuki Tsunemori, Mikio Sugimoto

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

Research Randomizer
SPSS

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