The clinical efficacy of topical and systemic therapy for the treatment of feline ocular chlamydiosis

Journal of Feline Medicine and Surgery
A H SparkesT J Gruffydd-Jones

Abstract

Twenty-four specific-pathogen-free-derived cats aged four to 11 months were challenged by ocular application of a field isolate of Chlamydia psittaci to evaluate the effect of topical and systemic therapy on the course of disease. The cats were monitored for 35 days post-challenge, with severity of clinical signs being measured using a scoring system, and ocular shedding of the organism monitored by culture of conjunctival swabs. All cats developed active C psittaci infection, and after 7 days the cats were randomly assigned to one of four treatment groups: Group P (placebo) was given twice-daily ophthalmic tear-replacement ointment; group F was given twice-daily topical 1% fusidic acid ophthalmic viscous drops; group C was given twice-daily topical 1% chlortetracycline ophthalmic ointment; and group D was given doxycycline at 10 mg/kg daily per os in addition to twice-daily topical 1% fusidic acid ophthalmic ointment. Within 24 h of commencement of therapy, group D had significantly lower median clinical scores than group P, and with the exception of day 16, this trend was maintained throughout the observation period. Median clinical scores of cats in group F were not appreciably different to those in group P, whereas the medi...Continue Reading

References

Nov 1, 1987·Infection and Immunity·J M WillsF J Bourne
Mar 1, 1983·Veterinary Pathology·A M HargisE T Gaillard
Nov 1, 1981·Australian Veterinary Journal·M J StuddertH J Wirth
Apr 8, 1995·The Veterinary Record·D A Gunn-MooreT J Gruffydd-Jones

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Citations

Jun 2, 2009·Journal of Feline Medicine and Surgery·Tim Gruffydd-JonesMarian C Horzinek
Nov 19, 2003·Journal of Feline Medicine and Surgery·W M A OwenT J Gruffydd-Jones

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