PMID: 3934405Nov 1, 1985

The clinical evaluation of plasma fibronectin as a marker for nutritional depletion and repletion and as a measure of nitrogen balance

JPEN. Journal of Parenteral and Enteral Nutrition
D F KirbyP Middaugh

Abstract

Plasma fibronectin has been suggested as a possible marker for nutritional repletion or depletion. This study was undertaken to evaluate the usefulness of plasma fibronectin in patients who received intense nutritional support. Twenty-seven patients referred to our Nutritional Support Services were followed for 3 to 5 wk; 22 received parenteral hyperalimentation alone, two received enteral alone, and three received a combination of both. Plasma fibronectin, serum albumin, serum transferrin, total lymphocyte counts, and 24-hr urine nitrogen balance studies were performed weekly; anthropometric measurements were performed every other week. Plasma fibronectin concentration, measured by laser nephelometry, showed a significant rise (p less than 0.005) in all patients after 1 wk of nutritional therapy; however, there was no significant difference among the subsequent weeks. Plasma fibronectin did not correlate with nitrogen balance studies, serum albumin, or total lymphocyte counts. A correlation between serum transferrin and plasma fibronectin was found not to be clinically useful. Thus, plasma fibronectin is sensitive to nutritional repletion after 1 wk of therapy, but is not useful thereafter. The relationship among nutritional s...Continue Reading

References

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Citations

May 7, 1996·Journal of the International Federation of Clinical Chemistry·A ShenkinB Isaksson
Mar 1, 2003·Clinics in Geriatric Medicine·M Louay Omran, Pascale Salem

Related Concepts

Blood Urea Nitrogen Measurement
Force Feeding
Fibronectins
Differential White Blood Cell Count Procedure
Nitrogen
Parenteral Nutrition, Total
Plasma Albumin
Transferrin C

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