The clinical evidence of second-generation H1-antihistamines in the treatment of allergic rhinitis and urticaria in children over 2 years with a special focus on rupatadine.

Expert Opinion on Pharmacotherapy
Antonio NietoÁngel Mazón

Abstract

Many obstacles limit the development of pharmacologic studies in children, in particular ethical and practical issues. Therefore, although second-generation H1-antihistamines (sgAH) are recommended by international guidelines as first-line therapy in childhood allergies, most data on the efficacy of antihistamines in children has been extrapolated from studies in adult patients. The current review focuses on rupatadine, a well-studied modern sgAH that has dual affinity for histamine H1-receptors and PAF receptors. In recent years, clinical efficacy and safety controlled-clinical trials on rupatadine were conducted in children and were based on latest current guidelines using validated tools of allergic rhinitis and urticaria. Children are not little adults since they present specific physiologic, metabolic, and developmental differences that should be evaluated in specific trials. The clinical evidence with rupatadine in children is the most recent and validated in accordance with current recommendations, with extensive direct data on efficacy and safety in pediatric populations over 2 years old.

References

Jul 31, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·D F GraftJ Long
Jul 31, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·M La RosaI Grimaldi
Apr 22, 2003·The Journal of Allergy and Clinical Immunology·Ulrich WahnErik Ruuth
Jun 24, 2004·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Eli O MeltzerErik Ruuth
Feb 11, 2005·Current Medical Research and Opinion·Melvyn BloomJerry Herron
Apr 28, 2005·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Jacques de BlicMarie-Christine Pujazon
Sep 3, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Paul C Potter, UNKNOWN Paediatric Levocetirizine Study Group
Jan 24, 2006·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Shuei-Tu ChenMing-Chih Chou
Oct 6, 2006·Expert Opinion on Pharmacotherapy·César Picado
Mar 10, 2007·International Journal of Pediatric Otorhinolaryngology·E A DizdarA Tuncer
Jun 15, 2007·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·F Estelle R Simons, UNKNOWN Early Prevention of Asthma in Atopic Children (EPAAC) Study Group
Oct 19, 2007·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Henry MilgromFrank C Hampel
Apr 11, 2008·Allergy·J MullolP Van Cauwenberge
Sep 11, 2008·Allergy·F M de BenedictisG W Canonica
Jan 10, 2009·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Antonio ValeroIñaki Izquierdo
May 15, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P KunaUNKNOWN Bilastine International Working Group
Jul 25, 2009·Allergy·J BousquetUNKNOWN ACCEPT-1 study group
Feb 12, 2010·Allergy·M K ChurchUNKNOWN Global Allergy and Asthma European Network
Dec 28, 2010·Inflammation & Allergy Drug Targets·Francesco MarcucciCristoforo Incorvaia
Jan 26, 2011·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ignacio JáureguiAntonio Valero
Nov 15, 2011·Current Medical Research and Opinion·Joaquín SastreUNKNOWN Bilastine Study Group
Dec 12, 2012·Acta Dermato-venereologica·Carlo CaffarelliRoberto Bernardini
Dec 20, 2012·Current Allergy and Asthma Reports·Adriana Izquierdo-DomínguezJoaquim Mullol
Feb 7, 2013·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Paul PotterAntonio Nieto
Feb 7, 2014·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Rosa Muñoz-CanoCesar Picado
Aug 26, 2014·Archives of Disease in Childhood. Education and Practice Edition·Roisin FitzsimonsHelen A Brough
Dec 11, 2014·Allergy·J MullolG Scadding
Jan 1, 2014·Allergo Journal International·Soja ShamizadehJohannes Ring
Aug 13, 2015·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Paul PotterMarcus Maurer
Feb 27, 2016·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Zoltán NovákUNKNOWN “Bilastine Paediatric Safety Study Group”
Aug 9, 2016·Expert Opinion on Drug Safety·Vanesa González-NúñezJoaquim Mullol

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