The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease

Clinics in Liver Disease
A J McCullough

Abstract

Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common chronic liver disease in the United States. The histologic spectrum of NAFLD ranges from steatosis liver alone to nonalcoholic steatohepatitis (NASH), which is the most serious form of NAFLD. NASH is a progressive fibrotic disease, in which cirrhosis and liver-related death occur in up to 20% and 12%, respectively, over a 10-year period. NASH-associated cirrhosis also can develop into subacute liver failure, progress to hepatocellular carcinoma, and reoccur post-transplantation. In contrast, steatosis alone has a more benign clinical course, although progression to cirrhosis has occurred in 3% of these patients. The major risk factors for fibrosis include diabetes or obesity, an aspartate aminotransferase/alanine aminotransferase ratio of greater than 1, age older than 50, and hepatic histology.

References

Feb 1, 1991·AJR. American Journal of Roentgenology·H LevensonR Buxton
Mar 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L M FletcherJ W Halliday
Nov 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I R Wanless, J S Lentz
Jan 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E E PowellL W Powell
Sep 15, 1989·Annals of Internal Medicine·M M Van Ness, A M Diehl
Dec 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M R TeliC P Day
May 1, 1995·Journal of Magnetic Resonance Imaging : JMRI·R LongoB de Bernard
May 1, 1995·Gastroenterology·A PropstW Vogel
Jan 1, 1997·Magnetic Resonance Imaging·M H FishbeinM A Smith
Dec 31, 1997·Journal of Clinical Gastroenterology·K TajiriC Sato
May 15, 1998·Diabetes Care·J M Fernández-RealJ Soler
Sep 2, 1998·AJR. American Journal of Roentgenology·J E JacobsS C Horii
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S H CaldwellC J Driscoll
May 29, 1999·Gastroenterology·C A MatteoniA J McCullough
Sep 25, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Z M YounossiA J McCullough
Nov 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P AnguloK D Lindor
Jan 12, 2000·Journal of Pediatric Gastroenterology and Nutrition·M Rashid, E A Roberts
Jan 22, 2000·Annals of Internal Medicine·S BellentaniC Tiribelli
Apr 27, 2000·The New England Journal of Medicine·D S Pratt, M M Kaplan
Jun 2, 2000·Gastroenterology·V RatziuT Poynard
Jun 28, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D G FongA L Buchman
Jul 25, 2000·Mayo Clinic Proceedings·K S Kumar, P F Malet
Sep 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A PoonawalaP J Thuluvath
Nov 4, 2000·The American Journal of Medicine·V M StrubenS H Caldwell
Apr 12, 2001·Seminars in Liver Disease·Y Falck-YtterA J McCullough
Apr 12, 2001·Seminars in Liver Disease·E S Siegelman, M A Rosen
Jul 19, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·M CharltonK P Batts
Feb 5, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shivakumar ChitturiJacob George
Mar 2, 2002·Journal of Clinical Gastroenterology·Arthur J McCullough
Apr 19, 2002·The New England Journal of Medicine·Paul Angulo
May 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vlad RatziuThierry Poynard
Jun 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Satheesh NairRobert P Perrillo
Aug 29, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alexander MontoTeresa L Wright
Sep 6, 2002·The New England Journal of Medicine·J Christian Bode
Apr 2, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giulio MarchesiniMario Rizzetto
May 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Pouneh MofradArun J Sanyal
Jun 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Thierry PoynardJanice Albrecht
Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jason M HuiJacob George
Aug 27, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Arthur J McCullough
Aug 27, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Brian L BresslerJenny Heathcote

❮ Previous
Next ❯

Citations

Mar 30, 2011·European Journal of Nutrition·Jesudoss Victor Antony SantiagoNamasivayam Nalini
Oct 7, 2009·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Gonca G BuralAbass Alavi
Feb 11, 2005·Current Gastroenterology Reports·Shane J Mills, Stephen A Harrison
Sep 4, 2008·Current Hypertension Reports·Matthew J BrookesBrian T Cooper
May 11, 2011·Hepatology International·Raj VuppalanchiUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)
Oct 25, 2011·Hepatology International·Julia O'Brien, Lawrie W Powell
Nov 17, 2009·World Journal of Pediatrics : WJP·H Hesham A-Kader
May 20, 2005·The Journal of Laboratory and Clinical Medicine·Claus A Pierach
Mar 29, 2007·Nature Clinical Practice. Gastroenterology & Hepatology·Masashi Yoneda
Oct 2, 2013·Nature Reviews. Gastroenterology & Hepatology·Gregory A MichelottiAnna Mae Diehl
Feb 3, 2007·Journal of Human Hypertension·M J Brookes, B T Cooper
Aug 19, 2006·Journal of Clinical Gastroenterology·Matthew W Pantsari, Stephen A Harrison
Aug 19, 2006·Anti-cancer Drugs·Chien-Liang LiuTsang-Pai Liu
Feb 10, 2010·Menopause : the Journal of the North American Menopause Society·Oksana A MatvienkoKenneth J Koehler
Mar 1, 2012·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Gabriela Salim Ferreira de CastroHelio Vannucchi
Jul 7, 2009·Annual Review of Nutrition·Linda Wasserbach YorkGeorge Y Wu
Feb 24, 2007·The Journal of Clinical Investigation·Varman T SamuelGerald I Shulman
Dec 27, 2005·Comparative Hepatology·Thierry PoynardJanice Albrecht
May 26, 2012·Journal of Lipid Research·Chen-Yu WangAlan D Attie
Mar 22, 2008·Pediatric Research·Lucia PacificoClaudio Chiesa
Apr 29, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yasar ColakFeruze Yilmaz Enc
Jun 23, 2009·AJR. American Journal of Roentgenology·Bachir TaouliScott B Reeder
Aug 9, 2013·International Journal of Environmental Research and Public Health·Pikkel JosefAssy Nimer
Sep 28, 2010·World Journal of Gastroenterology : WJG·Yu-Tao Zhan, Wei An
Oct 13, 2010·World Journal of Gastroenterology : WJG·Carmen Fierbinteanu-BraticeviciCatalin Carstoiu
Apr 18, 2012·World Journal of Gastroenterology : WJG·Masahide HamaguchiJun Takeda
May 16, 2013·World Journal of Gastroenterology : WJG·Lydia GiannitrapaniGiuseppe Montalto
Nov 28, 2008·Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe Chi·Jae-Hee YuYong-Sang Park
Dec 25, 2009·Radiology·Catherine D G HinesScott B Reeder

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Related Papers

Clinics in Liver Disease
Janus P Ong, Zobair M Younossi
The New England Journal of Medicine
Paul Angulo
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Jeffrey D BrowningHelen H Hobbs
Diabetic Medicine : a Journal of the British Diabetic Association
Leon A Adams, Paul Angulo
© 2021 Meta ULC. All rights reserved