The clinical impact of immediate on-site cytopathology evaluation during endoscopic ultrasound-guided fine needle aspiration of pancreatic masses: a prospective multicenter randomized controlled trial

The American Journal of Gastroenterology
Sachin WaniSteven Edmundowicz

Abstract

Observational data on the impact of on-site cytopathology evaluation (OCE) during endoscopic ultrasonography-guided fine needle aspiration (EUS-FNA) of pancreatic masses have reported conflicting results. We aimed to compare the diagnostic yield of malignancy and proportion of inadequate specimens between patients undergoing EUS-FNA of pancreatic masses with and without OCE. In this multicenter randomized controlled trial, consecutive patients with solid pancreatic mass underwent randomization for EUS-FNA with or without OCE. The number of FNA passes in the OCE+ arm was dictated by the on-site cytopathologist, whereas seven passes were performed in OCE- arm. EUS-FNA protocol was standardized, and slides were reviewed by cytopathologists using standardized criteria for cytologic characteristics and diagnosis. A total of 241 patients (121 OCE+, 120 OCE-) were included. There was no difference between the two groups in diagnostic yield of malignancy (OCE+ 75.2% vs. OCE- 71.6%, P=0.45) and proportion of inadequate specimens (9.8 vs. 13.3%, P=0.31). Procedures in OCE+ group required fewer EUS-FNA passes (median, OCE+ 4 vs. OCE- 7, P<0.0001). There was no significant difference between the two groups with regard to overall procedure ...Continue Reading

References

Sep 1, 2000·Gastrointestinal Endoscopy·H R MertzS D Leach
Jan 31, 2002·Gastrointestinal Endoscopy·Gordon C Hunt, Douglas O Faigel
Jan 4, 2003·BMJ : British Medical Journal·Patrick M BossuytUNKNOWN Standards for Reporting of Diagnostic Accuracy
Jun 24, 2003·The American Journal of Gastroenterology·Jason B KlapmanIrving Waxman
Mar 27, 2004·Gastrointestinal Endoscopy·Julia Kim LeBlancEdith Collins
Sep 1, 2005·Statistics in Medicine·John M Lachin
Jan 28, 2009·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Fahad AlsohaibaniGurpal Singh Sandha
Oct 23, 2009·Gastrointestinal Endoscopy·Brian G TurnerWilliam R Brugge
Mar 26, 2010·Annals of Internal Medicine·Kenneth F SchulzUNKNOWN CONSORT Group
Jul 6, 2010·Gastrointestinal Endoscopy·Patrick ClevelandMichael B Wallace
Jul 14, 2010·Gastrointestinal Endoscopy·Saowanee NgamruengphongAnanya Das
Jul 29, 2010·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·P Thomas CherianBrinder S Mahon
Feb 18, 2011·Digestive Diseases and Sciences·Sachin WaniAmit Rastogi
Apr 26, 2011·Gastrointestinal Endoscopy·Amit RastogiMojtaba Olyaee
Jan 13, 2012·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jan 18, 2012·Gastrointestinal Endoscopy·Michael Jonathan HewittKevin J Monahan
Jan 28, 2012·CA: a Cancer Journal for Clinicians·Edgar P SimardAhmedin Jemal
Jul 5, 2012·Cancer Cytopathology·Gilda da Cunha SantosWilliam R Geddie
Sep 7, 2012·The American Journal of Gastroenterology·Robert L Schmidt, Douglas G Adler
Oct 30, 2013·Diagnostic Cytopathology·Ruth Shifa Ecka, Malay Sharma
Nov 13, 2013·Gastrointestinal Endoscopy Clinics of North America·Larissa L Fujii, Michael J Levy
Dec 2, 2014·Gastrointestinal Endoscopy·Sachin WaniSrinadh Komanduri
Dec 3, 2014·The American Journal of Gastroenterology·Sachin WaniJeffrey L Tokar
Dec 7, 2014·Gastrointestinal Endoscopy·Sachin WaniJeffrey L Tokar

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Citations

Jun 25, 2016·Future Oncology·Emmanuel Coronel, Irving Waxman
Mar 17, 2017·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Gregory A Coté
Dec 28, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Mehdi MohamadnejadSachin Wani
Feb 22, 2018·Cancers·Pujan Kandel, Michael B Wallace
Oct 14, 2017·United European Gastroenterology Journal·Antonio FacciorussoNicola Muscatiello
Feb 28, 2019·Journal of Gastroenterology·Pujan Kandel, Michael B Wallace
Oct 9, 2019·Journal of Clinical Medicine·Yung-Yeh SuHong-Ming Tsai
Oct 12, 2019·Endoscopic Ultrasound·Fei YangSiyu Sun
Mar 13, 2020·Minerva gastroenterologica e dietologica·Antonio Facciorusso
Feb 23, 2019·United European Gastroenterology Journal·Elia ArmelliniStefano Francesco Crinò
Dec 28, 2017·Diagnostic Cytopathology·Sambit K MohantyMala Gupta
Dec 10, 2019·Clinical Endoscopy·Jae Keun Park, Kwang Hyuck Lee
Jul 14, 2020·Endoscopic Ultrasound·Bojan Kovacevic, Peter Vilmann
Nov 8, 2016·World Journal of Gastroenterology : WJG·Andrew C Storm, Linda S Lee
Dec 29, 2020·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Serena StiglianoFrancesco Maria Di Matteo
Feb 5, 2021·Scandinavian Journal of Gastroenterology·Giovanna Del Vecchio BlancoOmero Alessandro Paoluzi
Nov 10, 2020·Gastroenterology Report·Lindsey M TemnykhMohammad A Al-Haddad
May 13, 2021·Gastrointestinal Endoscopy·Sridevi K PokalaSachin Wani
Jun 4, 2021·Endoscopy International Open·Samuel HanUNKNOWN Collaborative Alliance for Pancreatic Education and Research (CAPER)
Jul 23, 2021·Der Pathologe·Lena HäberleIrene Esposito

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