The Clinical Impact of Infection with Swine Flu (H1N109) Strain of Influenza Virus in Hematopoietic Stem Cell Transplant Recipients

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Biju GeorgeMark Hertzberg

Abstract

There are limited data on the impact of H1N109 infection in patients undergoing hematopoietic stem cell transplantation (HSCT). We reviewed individual medical records of patients who underwent HSCT or were on follow-up post-HSCT between May and September 2009. Thirteen patients with H1N109 infection were identified: 2 <100 days post-HSCT, 7 >100 days post-HSCT, and 4 just prior to HSCT. Five (38.7%) had lower respiratory tract involvement (LRTI), whereas the remainder had upper respiratory tract involvement (URTI). LRTI occurred in patients who were profoundly neutropenic post-HSCT or on potent immunosuppression for chronic graft-versus-host disease (cGVHD). At 100 days post-H1N109 infection, only 1 patient with LRTI survived, whereas all with URTI are alive. Four patients successfully treated for H1N109 infection prior to HSCT underwent the procedure after 4 to 6 weeks without any complications. Another 6 patients received oseltamivir prophylaxis during conditioning and none developed H1N109 infection. In conclusion, H1N109 infection was associated with LRTI in HSCT recipients who were profoundly neutropenic or immunosuppressed. Prior H1N109 infection did not affect the successful outcome of HSCT and oseltamivir prophylaxis in...Continue Reading

References

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Citations

Jul 28, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E CorderoUNKNOWN Novel Influenza A(H1N1) Study Group of the SpanishNetwork for Research in Infectious Diseases (REIPI)
Mar 23, 2011·Bone Marrow Transplantation·B MohtyY Chalandon
Dec 27, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Natasha B HalasaMadan Jagasia
Nov 15, 2013·Influenza and Other Respiratory Viruses·Michael G Ison
Sep 28, 2012·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S GhoshR Meisel
Feb 26, 2011·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S H LeeC W Jung
Jul 31, 2013·Transplant Infectious Disease : an Official Journal of the Transplantation Society·G ReidD Kumar
Feb 18, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Saskia GuellerGesine Bug
Sep 17, 2016·Infectious Diseases·Urshila DuraniAaron J Tande
Aug 30, 2017·Journal of Medical Virology·Diana Vilar-CompteRoy F Chemaly

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