The clinical impact of pitavastatin: comparative studies with other statins on LDL-C and HDL-C

Expert Opinion on Pharmacotherapy
Tamio Teramoto

Abstract

Statins are currently the most effective drugs for lowering low-density lipoprotein cholesterol (LDL-C) and represent the first choice for treating hypercholesterolemia. Pitavastatin was launched as a new statin on the Japanese market in 2003, followed by Korea, Thailand, China, the United States and Europe. This review summarizes and evaluates new insights into pitavastatin, from clinical trials since 2010. This article reviews studies that compare pitavastatin with various other statins: i) Randomized Head-to-Head Comparison of Pitavastatin, Atorvastatin, and Rosuvastatin for Safety and Efficacy (Quantity and Quality of LDL): the PATROL Trial; ii) various Phase III clinical trials in Western countries; iii) The Comparison of Preventive Effect on Cardiovascular Events With Different Statins (CIRCLE) study; and iv) The Livalo Effectiveness and Safety (LIVES) Study Extension. Pitavastatin was found to have a similar LDL-C-lowering effect to other strong statins but also had a strong HDL-C-elevating effect and did not worsen glucose metabolism. Pitavastatin has been launched in various countries around the world as a statin with potent LDL-C-lowering activity that is virtually unmetabolized by the cytochrome P450 family, with rel...Continue Reading

References

Oct 12, 2004·Biochemical and Biophysical Research Communications·Takashi MaejimaY Saito
Jul 16, 2005·Journal of Atherosclerosis and Thrombosis·Atsuhito SaikiKohji Shirai
Mar 6, 2010·Expert Opinion on Pharmacotherapy·Tamio TeramotoMitsuyoshi Urashima
May 29, 2010·Current Vascular Pharmacology·Michael S KostapanosMoses S Elisaf
Apr 19, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Keijiro SakuUNKNOWN PATROL Trial Investigators
Jun 16, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Takao MaruyamaToshiaki Hasuike
Aug 30, 2011·Advances in Therapy·Mats ErikssonNeil Hounslow
Nov 17, 2011·The New England Journal of Medicine·Stephen J NichollsSteven E Nissen

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Citations

Nov 13, 2013·Expert Review of Cardiovascular Therapy·Vivencio BarriosJosé L Zamorano
Mar 9, 2013·Expert Review of Cardiovascular Therapy·Stella AslibekyanDonna K Arnett
Oct 26, 2013·Expert Opinion on Drug Metabolism & Toxicology·Miao Hu, Brian Tomlinson
Feb 26, 2014·Scandinavian Journal of Clinical and Laboratory Investigation·Hirokazu KakudaNoboru Takekoshi
Feb 14, 2013·Primary Care·Robert H Nelson
Jan 1, 2014·Journal of Surgical Oncology·Daniel E AbbottMichael J Edwards

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