PMID: 9421704Jan 9, 1998Paper

The clinical impact of resistance in the management of pneumococcal disease

Infectious Disease Clinics of North America
R J Leggiadro

Abstract

The prevalence of drug-resistant Streptococcus pneumoniae (DRSP) has increased worldwide. Although unfavorable outcomes in meningitis due to DRSP have been well-described, the clinical impact of DRSP on other manifestations of pneumococcal infection warrants further study. Empiric combination vancomycin and extended-spectrum cephalosporin (cefotaxime or ceftriaxone) therapy is indicated for the following clinical indications: purulent meningitis, life-threatening pneumonia, and suspected sepsis in patients predisposed to invasive pneumococcal disease, for example, sickle cell disease, HIV infection, and nephrotic syndrome. In addition to clinical management issues, other implications of the emergence of DRSP include identification of resistant strains, local and national surveillance, and prevention. Preventive measures include judicious antibiotic use, appropriate use of the currently available 23-valent pneumococcal vaccine, and development and implementation of a protein-conjugate vaccine.

References

Dec 1, 1992·The Journal of Infectious Diseases·M R ReichlerR O Walton
Jul 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P C Appelbaum
Feb 1, 1991·The Pediatric Infectious Disease Journal·V K WongK S Kim
Aug 24, 1995·The New England Journal of Medicine·J HofmannR F Breiman
Dec 1, 1994·The Pediatric Infectious Disease Journal·R J LeggiadroF C Tenover
Dec 29, 1994·The New England Journal of Medicine·H N Blansfield
Apr 1, 1996·The Journal of Infectious Diseases·C MaoH W Hsu
Oct 1, 1995·Antimicrobial Agents and Chemotherapy·M M ParísG H McCracken
Sep 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R E FrankelG Friedland
Oct 1, 1996·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M IlyasR J Wyatt

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Citations

Feb 13, 1999·Comprehensive Therapy·R L Lark, C Chenoweth
Mar 24, 1999·Ryōikibetsu shōkōgun shirīzu·M KurokiS Kohno
Dec 29, 2000·Comprehensive Therapy·M Gotfried, C Freeman
Nov 11, 1998·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·D H Spach, D Black
Jan 5, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A E FioreA Schuchat
Aug 5, 2000·The Pediatric Infectious Disease Journal·S Perez MatoR E Bégué
Sep 14, 2000·Australian and New Zealand Journal of Medicine·J G McCormack
May 3, 2001·Enfermedades infecciosas y microbiología clínica·J RuizJ Gómez
May 29, 1999·The American Journal of Medicine·M R Jacobs
Nov 2, 2001·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F ParadisiR Cinelli
Apr 28, 2004·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·William A Rutala, David J Weber
Feb 23, 2000·Mayo Clinic Proceedings·A Virk, J M Steckelberg
Nov 30, 2000·Current Infectious Disease Reports·M A Mufson
Aug 17, 2004·Infectious Disease Clinics of North America·Keith S KayeElias Abrutyn
Jun 1, 2000·Infectious Disease Clinics of North America·K S KayeE Abrutyn

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