The clinical impact of the detection of potential etiologic pathogens of community-acquired pneumonia

Diagnostic Microbiology and Infectious Disease
Gita GelferDavid N Gilbert

Abstract

The etiology of community-acquired pneumonia (CAP) is determined in less than half of the patients based on cultures of sputum and blood plus testing urine for the antigens of Streptococcus pneumoniae and Legionella pneumophila. This study added nasal polymerase chain reaction (PCR) probes for S. pneumoniae, Staphylococcus aureus, and respiratory viruses. Serum procalcitonin (PCT) levels were measured. Pathogens were identified in 78% of the patients. For detection of viruses, patients were randomized to either a 5-virus laboratory-generated PCR bundle or the 17-virus FilmArray PCR platform. The FilmArray PCR platform detected more viruses than the laboratory-generated bundle and did so in less than 2 hours. There were fewer days of antibiotic therapy, P = 0.003, in CAP patients with viral infections and a low serum PCT levels.

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Citations

Oct 30, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kimberly E Hanson, Marc Roger Couturier
Jun 8, 2017·Emerging Microbes & Infections·Kelvin Kw ToKwok-Yung Yuen
Jan 10, 2017·Current Opinion in Infectious Diseases·Davide Leoni, Jordi Rello
Dec 22, 2017·Journal of the American Geriatrics Society·Joseph M Mylotte
Jan 15, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Şiran KeskeFüsun Can
Mar 9, 2018·Journal of Clinical Microbiology·Şiran KeskeÖnder Ergönül
May 27, 2016·Journal of Clinical Microbiology·Urania RappoMarshall J Glesby
Jan 29, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Laura M VosJan Jelrik Oosterheert
Feb 8, 2020·Journal of Clinical Laboratory Analysis·Anna Theresa ReischlStephan Gehring
Nov 16, 2016·Open Forum Infectious Diseases·Brad SpellbergDavid N Gilbert
Mar 3, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·D BouzidV Cattoir

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Methods Mentioned

BETA
PCR
bronchoalveolar lavage
PCRs

Software Mentioned

Filemaker

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