The clinical impact of using complex molecular profiling strategies in routine oncology practice

Oncotarget
Jean-François LaesHelen Sadik

Abstract

Molecular profiling and functional assessment of signalling pathways of advanced solid tumours are becoming increasingly available. However, their clinical utility in guiding patients' treatment remains unknown. Here, we assessed whether molecular profiling helps physicians in therapeutic decision making by analysing the molecular profiles of 1057 advanced cancer patient samples after failing at least one standard of care treatment using a combination of next-generation sequencing (NGS), immunohistochemistry (IHC) and other specific tests. The resulting information was interpreted and personalized treatments for each patient were suggested. Our data showed that NGS alone provided the oncologist with useful information in 10-50% of cases (depending on cancer type), whereas the addition of IHC/other tests increased extensively the usefulness of the information provided. Using internet surveys, we investigated how therapy recommendations influenced treatment choice of the oncologist. For patients who were still alive after the provision of the molecular information (76.8%), 60.4% of their oncologists followed report recommendations. Most treatment decisions (93.4%) were made based on the combination of NGS and IHC/other tests, and...Continue Reading

References

Mar 20, 2010·Clinical Pharmacology and Therapeutics·F StegmeierM Dorsch
May 16, 2012·Cancer Discovery·Levi A Garraway, Pasi A Jänne
Feb 28, 2013·American Journal of Medical Genetics. Part a·Mehdi NajafzadehCarlo Marra
May 28, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Funda Meric-BernstamGordon B Mills
Jun 2, 2015·Nature Medicine·Giulia SiravegnaAlberto Bardelli
Oct 17, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lillian L SiuPatricia M LoRusso
Feb 7, 2017·Journal of Clinical Pharmacy and Therapeutics·M M SaiyedL Chew
Apr 7, 2017·Journal of Cancer·Maonan WangCan Guo
Apr 13, 2017·Expert Review of Molecular Diagnostics·Cara M StatzSusan M Mockus
Sep 12, 2017·JCO Precision Oncology·Debyani ChakravartyNikolaus Schultz

❮ Previous
Next ❯

Citations

Dec 8, 2019·Clinical Chemistry·Ge Gao, David I Smith
Mar 18, 2020·AJR. American Journal of Roentgenology·Daniel A SmithNikhil H Ramaiya
Aug 7, 2019·Oncotarget·Mary K NeslineCarl Morrison

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
biopsies
Assay
chip

Software Mentioned

OncoDEEP
Package Plus
Variant Caller
Torrent Suite
Genescan
Ensembl
OncoKB

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.