The clinical implications of ageing for rational drug therapy

European Journal of Clinical Pharmacology
Shaojun ShiUlrich Klotz

Abstract

The proportion of the elderly is constantly increasing and by the year 2025 20% of the population will be above 65 years of age. With advanced age, subjects will develop multiple diseases and often need to take several drugs. This polypharmacy increases the risk for drug interactions and adverse effects. In addition, age-related physiological changes affect different biological systems and can contribute to alterations in pharmacokinetics and pharmacodynamics in older patients, which are more often seen in the frail than in the fit elderly. These features will complicate drug therapy in the elderly, and a careful dose titration is advisable. Furthermore, inappropriate drug prescription and non-adherence to medication represent common therapeutic challenges in elderly subjects. To date, there is no evidence of any effective antiageing agent. This review summarizes present knowledge of age-related problems in drug action and their clinical implications for an increasingly important population.

References

Aug 1, 1979·Clinical Pharmacology and Therapeutics·R E VestalD G Shand
Feb 1, 1975·The Journal of Clinical Investigation·U KlotzG R Wilkinson
Nov 1, 1990·Clinical Pharmacokinetics·C DurnasB J Cusack
Nov 1, 1990·Age and Ageing·H A WynneK W Woodhouse
Mar 1, 1990·Age and Ageing·J SummerbellK Woodhouse
Jan 1, 1990·British Medical Bulletin·K W Woodhouse, O F James
Jan 1, 1989·Age and Ageing·F M WilliamsM D Rawlins
Apr 1, 1985·Journal of the American Geriatrics Society·R D LindemanN W Shock
Sep 1, 1970·Metabolism: Clinical and Experimental·G B Forbes, J C Reina
Jan 1, 1984·British Journal of Clinical Pharmacology·R O DaviesJ F Walker
Feb 1, 1995·Journal of the American Geriatrics Society·J R SaltzmanR M Russell
Aug 1, 1996·Journal of the American Geriatrics Society·J DoucetE Bercoff
Feb 1, 1996·British Journal of Anaesthesia·W W Mapleson
Aug 1, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·D FliserE Ritz
Jul 1, 1997·Age and Ageing·K W Woodhouse, M S O'Mahony
Aug 27, 1997·JAMA : the Journal of the American Medical Association·M Feldman
Oct 29, 1997·Clinical Pharmacokinetics·M T Kinirons, P Crome
Nov 21, 1997·BMJ : British Medical Journal·P A Rochon, J H Gurwitz
Dec 10, 1997·Gut·O F James
May 21, 1998·Clinical Pharmacokinetics·D G Le Couteur, A J McLean
Oct 1, 1998·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·D L Schmucker
Apr 29, 1999·Drugs & Aging·R J Beyth, R I Shorr
Jul 3, 1999·Clinical Pharmacology and Therapeutics·S AlbrechtJ Schüttler
Apr 14, 2000·Journal of Gastroenterology and Hepatology·K HarumaA Miyoshi
May 10, 2000·Drugs & Aging·B A SprouleK I Shulman
Aug 11, 2000·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·M KuzuyaA Iguchi
Aug 17, 2000·Clinical Pharmacology and Therapeutics·G K DresserS G Carruthers
Aug 31, 2000·Aging : Clinical and Experimental Research·M SchwabU Klotz
Nov 23, 2000·Nature·T Finkel, N J Holbrook
Feb 24, 2001·Drugs & Aging·C G HanrattyA P Passmore
Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·A B NewmanUNKNOWN Cardiovascular Health Study Research Group
Jan 16, 2002·JAMA : the Journal of the American Medical Association·David W KaufmanAllen A Mitchell
Feb 28, 2002·Best Practice & Research. Clinical Gastroenterology·C Herrlinger, U Klotz
Mar 22, 2002·Clinical Pharmacology and Therapeutics·Leslie Z Benet, Betty-ann Hoener

❮ Previous
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Citations

Jan 1, 2012·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Fabrizia LattanzioAndrea Corsonello
Oct 7, 2011·Medizinische Klinik, Intensivmedizin und Notfallmedizin·P A Thürmann, S Schmiedl
Apr 7, 2011·International Urogynecology Journal·Karin Glavind, Michael Chancellor
Sep 10, 2013·Journal of Cross-cultural Gerontology·Peri J BallantyneHeather Boon
May 18, 2013·Drugs & Aging·Marianne LeaEspen Molden
Jun 1, 2011·Canadian Journal on Aging = La Revue Canadienne Du Vieillissement·Peri J BallantyneJudith E Fisher
Jan 16, 2010·The Nurse Practitioner·Tamara Zurakowski
Feb 7, 2009·International Journal of Clinical Practice·R H E De SmedtT Jaarsma
Feb 28, 2009·Stroke; a Journal of Cerebral Circulation·Marc FisherUNKNOWN STAIR Group
Dec 2, 2011·Journal of Strength and Conditioning Research·Jay R SalmonMark D Tillman
Feb 27, 2010·Drugs & Aging·Andrea CorsonelloFabrizia Lattanzio
Jan 20, 2012·Clinical Pharmacokinetics·Shaojun Shi, Ulrich Klotz
May 31, 2012·Drugs & Aging·Antonio CherubiniFabrizia Lattanzio
Feb 20, 2014·Indian Journal of Pharmacology·Chaitali S BajaitAmruta V Dawri
Dec 19, 2013·Nature Reviews. Gastroenterology & Hepatology·Christina Y Ha, Seymour Katz
Aug 16, 2014·Journal of Geriatric Oncology·Laura K SaarelainenJ Simon Bell
Feb 28, 2009·Women's Health·Seine ChiangHolly E Richter
Jan 1, 2012·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Carlos ChiattiFabrizia Lattanzio
Jan 18, 2013·Informatics for Health & Social Care·Blaine ReederKaren D Marek
Jun 12, 2009·Drug Metabolism Reviews·Ulrich Klotz
Jan 21, 2015·Expert Opinion on Drug Metabolism & Toxicology·Emily ReeveArduino A Mangoni
Feb 26, 2016·Archives of Gerontology and Geriatrics·Maarten WautersMajda Azermai
May 15, 2013·Zeitschrift für Evidenz, Fortbildung und Qualität im Gesundheitswesen·Petra A Thürmann
Nov 8, 2015·European Journal of Clinical Pharmacology·Consuelo PedrósJosep Maria Arnau
Apr 17, 2012·Clinics in Geriatric Medicine·Leah Church Sera, Mary Lynn McPherson
Jan 23, 2016·Archives of Gerontology and Geriatrics·Åsa Gransjön CraftmanEva von Strauss
Feb 1, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A CorsonelloF Lattanzio
Jul 3, 2010·Critical Reviews in Oncology/hematology·V GirreL Mignot
Sep 6, 2015·Journal of the American Medical Directors Association·Jonas W WastessonKristina Johnell
Oct 27, 2015·Disease-a-month : DM·Mitch King, Martin S Lipsky
Aug 8, 2009·British Journal of Clinical Pharmacology·Danijela GnjidicSarah N Hilmer
Jul 30, 2011·Journal of the American Geriatrics Society·Maarit S DimitrowSaija N S Leikola
Mar 20, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kristina Johnell
May 12, 2010·Journal of Clinical Pharmacy and Therapeutics·V MaioUNKNOWN GAP Investigators
Apr 15, 2015·British Journal of Clinical Pharmacology·Andreas D MeidWalter E Haefeli

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