The clinical implications of G1-G6 transcriptomic signature and 5-gene score in Korean patients with hepatocellular carcinoma

BMC Cancer
Sung-Min AhnEunsil Yu

Abstract

Efforts have been made to classify Hepatocellular Carcinoma (HCC) at surgically curable stages because molecular classification, which is prognostically informative, can accurately identify patients in need of additional early therapeutic interventions. Recently, HCC classification based French studies on the expression of 16 genes and 5 genes were proposed. In 16-gene classification, transcriptomic signatures (G1-G6) were used to classify HCC patients into clinical, genomic and pathway-specific subgroups. In 5-gene score classification, the good or poor prognosis of HCC patients was predicted. The patient's cohort in these studies was mainly from Caucasian and African populations. Here, we aimed to validate G1-G6 and 5-gene score signatures in 205 Korean HCC patients since genomic profiles of Korean patients are distinct from other regions. Integrated analyses using whole-exome sequencing, copy number variation and clinical data was performed against these two signatures to find statistical correlations. Kaplan-Meier, univariate and multivariate COX regression analysis were performed for Disease-Specific Survival (DSS) and Recurrence-Free Survival (RFS). The G2 and G3 subgroups of transcriptomic signature were significantly as...Continue Reading

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Citations

Feb 6, 2021·Journal of Hepatology·Aurélie BeaufrèreValérie Paradis
Oct 9, 2021·Journal of Cancer Research and Clinical Oncology·Aroosha Raja, Farhan Haq

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Methods Mentioned

BETA
have surgical resection
exome sequencing

Software Mentioned

Nexus Copy Number
MuTect

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Carcinoma, Hepatocellular

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