Feb 25, 2020

The Clinical Management of Clonal Hematopoiesis: Creation of a Clonal Hematopoiesis Clinic

Hematology/oncology Clinics of North America
Kelly L BoltonRoss L Levine

Abstract

The acquisition of mutations in hematologic stem cells (clonal hematopoiesis) is common with normal aging and can be identified as an incidental finding through clinical genetic testing. Clonal hematopoiesis is associated with a heightened risk of developing hematologic neoplasms (especially myeloid) and accelerated atherosclerotic cardiovascular disease. This article discusses a multidisciplinary clinical approach to the management of patients with clonal hematopoiesis. Key areas of research needed to establish evidence-based clinical care guidelines and intervention strategies for individuals with clonal hematopoiesis are discussed.

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Mentioned in this Paper

Clinic
Atherosclerosis
Neoplasms
Hematopoiesis
Disease Management
Clone
Finding
Genetic Screening Method
Stem Cells
Aging

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