The clinical outcome of cardiac resynchronization therapy in post-surgical valvular cardiomyopathy
Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Francisco LeyvaMichael P Frenneaux
Abstract
Trials have shown that cardiac resynchronization therapy (CRT) is effective in patients with 'non-ischaemic cardiomyopathy'. Patients with post-surgical valvular cardiomyopathy (PSVCM) have been excluded from such trials. We sought to compare the clinical outcome of CRT in patients with PSVCM, idiopathic dilated cardiomyopathy (IDCM), or ischaemic cardiomyopathy (ICM). Clinical events and response to CRT were quantified in 556 patients (PSVCM = 38; IDCM = 165; ICM = 353) over 4.52 years [median, inter-quartile range (IQR): 4.42]. Response to CRT was defined as survival for ≥1 year free of hospitalizations plus improvement by ≥1 NYHA class or ≥25% in 6-min walking distance. Cardiac resynchronization therapy was initiated at 5.86 years (median, IQR: 9.86) after aortic valve replacement (73.7%) or mitral valve replacement/repair (44.7%). Compared with PSVCM, IDCM was associated with a lower total mortality [hazards ratio, HR: 0.54 (95% confidence interval, CI 0.34-0.84)], cardiac mortality [HR: 0.43 (95% CI 0.26-0.70)], and total mortality or major adverse cardiovascular events [HR: 0.57 (95% CI 0.37-0.87)], independent of known confounders. Compared with PSVCM, ICM was associated with a similar risk of death from pump failure [HR...Continue Reading
References
Dec 1, 1989·The American Journal of Cardiology·H A RockmanJ L Rouleau
Mar 1, 1996·Circulation·P RichardsonP Nordet
Sep 15, 2000·Journal of the American College of Cardiology·J S AlpertJ P Bassand
Apr 12, 2003·Pacing and Clinical Electrophysiology : PACE·Maurizio GaspariniEdoardo Gronda
May 21, 2004·The New England Journal of Medicine·Michael R BristowUNKNOWN Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Investigators
Mar 9, 2005·The New England Journal of Medicine·John G F ClelandUNKNOWN Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators
Jan 31, 2006·American Heart Journal·Maurizio MangiavacchiEdoardo Gronda
Oct 19, 2006·Journal of the American College of Cardiology·John J HayesUNKNOWN DAVID Investigators
Nov 23, 2006·Journal of the American College of Cardiology·Ravi G AssomullDudley J Pennell
Aug 19, 2007·Heart·David BarnettCarole Longson
May 26, 2009·JACC. Cardiovascular Interventions·Nicolo PiazzaPatrick W Serruys
Jun 12, 2009·European Heart Journal·Giuseppe BorianiUNKNOWN InSync/InSync ICD Italian Registry Investigators
Jul 22, 2009·American Heart Journal·Marcos GutiérrezEric Dumont
Sep 3, 2009·European Heart Journal·Kenneth DicksteinUNKNOWN National Coordinators
Dec 9, 2010·Interactive Cardiovascular and Thoracic Surgery·Iain G MatthewsAndrew J Turley
Jun 15, 2011·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Francisco LeyvaAngelo Auricchio
Oct 2, 2012·Journal of the American College of Cardiology·Francisco LeyvaSanjay K Prasad
Oct 9, 2012·Journal of the American College of Cardiology·Marina UrenaJosep Rodés-Cabau
Nov 2, 2013·European Heart Journal·Tamim M NazifSusheel K Kodali
Mar 14, 2014·JACC. Heart Failure·Maurizio GaspariniFrancisco Leyva
Nov 13, 2014·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Gerhard SchymikArmin Luik
Citations
Nov 22, 2019·European Heart Journal·Sérgio BarraEloi Marijon
Jul 2, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Sérgio BarraSharad Agarwal