The clinical prognostic significance of ezrin in patients with bone and soft tissue sarcomas: a meta-analysis

FEBS Open Bio
Feng WangZhiyu Zhang

Abstract

Ezrin is a member of the ezrin-radixin-moesin (ERM) protein family and has been shown to be associated with poor prognosis in patients with a variety of solid tumors. However, the clinical prognostic significance of ezrin in patients with bone and soft tissue sarcomas remains unclear. Here, we performed a systematic meta-analysis by searching PubMed, the Cochrane Library Database, EMBASE, the Web of Science, and the CBM, WanFang Med Online and CNKI databases. In total, 19 studies with a total of 1316 bone and soft tissue sarcoma patients were included. Pooled analyses showed that ezrin overexpression was correlated with a higher rate of tumor metastasis (OR 6.59, 95% CI: 2.84-15.33, P < 0.01, PFDR  < 0.01) and recurrence (OR 3.18, 95% CI: 1.88-5.37, P < 0.01, PFDR  < 0.01) and a more advanced tumor grade (OR 3.252, 95% CI: 1.371-7.715, P = 0.01, PFDR  = 0.03). Moreover, elevated ezrin expression could predict poor OS (HR 3.02, 95% CI: 2.35-3.89, P < 0.01, PFDR  < 0.01), MFS (HR 5.22, 95% CI: 2.08-13.08, P < 0.01, PFDR  < 0.01), and EFS (HR 1.07, 95% CI: 1.03-1.11, P < 0.01, PFDR  < 0.01). Subgroup analyses revealed the underlying sources of heterogeneity. Publication bias was observed in the analysis of metastasis. Sensitivity ...Continue Reading

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