The clinical relevance of serum antinuclear antibodies in Japanese patients with systemic sclerosis.

The British Journal of Dermatology
Y HamaguchiS Sato

Abstract

Systemic sclerosis (SSc) is a connective tissue disorder with excessive fibrosis of the skin and various internal organs. Although SSc is a heterogeneous disease, it has been reported that the particular antinuclear antibodies (ANA) are often indicative of clinical features, disease course and overall severity. To clarify the association of clinical and prognostic features with serum ANA in Japanese patients with SSc. We studied 203 Japanese patients diagnosed with SSc, who visited our hospital during the period 1983-2005. Six SSc-related ANA were identified using indirect immunofluorescence, double immunodiffusion and immunoprecipitation assays. Patients with SSc were classified into six ANA-based subgroups and a group without ANA. As expected, antitopoisomerase I antibody (Ab, n=64), anti-RNA polymerases (RNAP) Ab (n=12) and anti-U3 RNP Ab (n=5) were associated with diffuse cutaneous SSc, whereas anticentromere Ab (ACA, n=75), anti-Th/To Ab (n=7) and anti-U1 RNP Ab (n=10) were frequently detected in patients with limited cutaneous SSc. Clinical features of the ANA-negative group (n=10) were heterogeneous. Consistent with previous findings in Caucasian and/or black African patients, antitopoisomerase I Ab was associated with t...Continue Reading

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Citations

Dec 29, 2012·Clinical Rheumatology·Jiucun WangXiaodong Zhou
Aug 30, 2011·Modern Rheumatology·Atsushi HashimotoShunsei Hirohata
Sep 20, 2012·Modern Rheumatology·Minoru HasegawaKazuhiko Takehara
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Methods Mentioned

BETA
immunoprecipitation
electrophoresis

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