The clinical results of a platelet glycoprotein IIb/IIIa receptor blocker (abciximab: ReoPro)-coated stent in acute myocardial infarction

Journal of the American College of Cardiology
Weon KimJung Chae Kang

Abstract

This study is a prospective randomized trial investigating clinical outcomes of patients with acute myocardial infarction (AMI) treated with abciximab (ReoPro)-coated stents. Recently we have demonstrated that abciximab-coated stents have inhibitory effects in the prevention of coronary restenosis. Ninety-six patients with AMI were randomly allocated into two groups; group I received abciximab-coated stents (n = 48, 57.1 +/- 12.0 years), and group II received bare metal control stents (n = 48, 58.4 +/- 11.6 years). At baseline, clinical characteristics, percent diameter stenosis, and minimal luminal diameter were no different between the two groups. One patient in group II had reinfarction and target lesion reintervention during hospital stay. Follow-up coronary angiography was obtained in 77.1% (37 of 48) in group I and 75.0% (36 of 48) in group II. Percent diameter stenosis and late loss were significantly lower in group I than group II (18.9 +/- 5.54% vs. 37.9 +/- 6.25%, p = 0.008; and 0.39 +/- 0.29 mm vs. 0.88 +/- 0.45 mm; p = 0.008, respectively). At follow-up intravascular ultrasound, intrastent lumen area and intrastent neointimal hyperplasia (NIH) area were 5.4 +/- 1.8 mm2 and 2.2 +/- 1.5 mm2, respectively, in group I a...Continue Reading

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Citations

Oct 13, 2007·Biomacromolecules·Hironobu TakahashiDavid W Grainger
Jan 28, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Sung Soo KimJung Chaee Kang
Feb 11, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Marco ZimarinoRaffaele De Caterina
Mar 1, 2008·Biologics : Targets & Therapy·Marco ValgimigliGianfranco Percoco
Dec 14, 2007·International Journal of Cardiology·Ki Hong LeeUNKNOWN Other Korea Acute Myocardial infarction Registry Investigators
May 28, 2009·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Marc Cohen
Mar 29, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jonathon ZhaoJohan Riesenfeld
Jul 17, 2007·Journal of the American College of Cardiology·Simon R DixonWilliam W O'Neill
Jul 25, 2013·Atherosclerosis·Blandine MaurelStephan Haulon
Nov 21, 2013·Korean Circulation Journal·Jae Yeong ChoMyung Ho Jeong
Feb 26, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Sang Yup LimJung Chaee Kang
Nov 6, 2007·Journal of Korean Medical Science·Young Joon HongJung Chaee Kang
Sep 18, 2007·Expert Review of Cardiovascular Therapy·Gregory DucrocqJean-Francois Tanguay
Oct 14, 2017·Chonnam Medical Journal·Doo Sun Sim, Myung Ho Jeong

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