The clinical significance of c-myc oncogene expression in melanomas of the scalp

British Journal of Plastic Surgery
J S ChanaA O Grobbelaar

Abstract

Melanomas of the scalp are rare and have a poorer prognosis than melanomas arising at other cutaneous sites. In order to study the biology of this disease, the activity of the c-myc oncogene was studied in tumours from 25 patients with scalp melanoma using the technique of flow cytometry. Survival analysis revealed that stratification of patients according to oncogene activity provided a prognostic marker with shorter overall survival (log rank test, chi 2 = 3.9, P = 0.05) in tumours with high nuclear c-myc oncoprotein positivity. These results support our previous studies of the prognostic value of c-myc expression in melanoma and suggest that estimation of c-myc oncoprotein may be of clinical significance in identifying high risk patients.

Citations

May 1, 2004·Seminars in Plastic Surgery·Steven M PisanoChet L Nastala
Nov 19, 2004·The British Journal of Ophthalmology·P N TulleyG D Wilson
Dec 17, 2008·World Journal of Gastroenterology : WJG·Guo-Yan LiuHong-Zhi Gao
Aug 17, 2001·Annals of Plastic Surgery·J S ChanaA O Grobbelaar
Jun 23, 1999·Oncogene·C E NesbitE V Prochownik
Dec 25, 2008·Nature Clinical Practice. Oncology·Allison R LarsonRhoda M Alani
Nov 29, 2001·Melanoma Research·M H NealeI A Cree
Aug 3, 2013·The American Journal of Dermatopathology·Krishna SinghLeslie Raffel
Nov 27, 2002·Cancer Investigation·Jochen UtikalGertraud M Krähn
Apr 9, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Barbara BucciAldo Vecchione

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