The clinical significance of concomitant bacteriuria in patients with Staphylococcus aureus bacteremia. A review and meta-analysis

Infectious Diseases
Stamatis Karakonstantis, Dimitra Kalemaki

Abstract

Staphylococcus aureus bacteriuria (SABU) concomitant to S. aureus bacteremia (SAB) has been associated with deep-seated infections and worse prognosis. However, the relevant studies were small and inconsistent. Here, we aim to provide a review of the relevant literature, and a meta-analysis of these studies. We searched PubMed and Scopus for studies comparing patients with SAB and concomitant SABU to patients with SAB without SABU. Nine relevant studies were identified, involving 1429 patients with SAB, of whom 18.5% (n = 265) had concomitant SABU. Pooling the results of those studies, SABU was significantly associated with endocarditis, bone/joint infection and septic embolism. SABU was also associated with persistent SAB, and higher mortality. Although SABU may be a useful marker of complicated SAB, the current literature has several limitations. Larger prospective studies are required to clarify the value of SABU in clinical decision making.

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Nov 13, 2017·Infection·Stamatis Karakonstantis, Dimitra Kalemaki

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Citations

Jun 22, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Valeria Fabre, Sara E Cosgrove
Jul 1, 2021·Open Forum Infectious Diseases·Franziska SchulerFrieder Schaumburg

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