The clinical significance of early proteinuria after renal transplantation

Transplantation
Aravind CherukuriRichard J Baker

Abstract

Late-onset proteinuria after renal transplantation has been universally associated with poor allograft outcomes. However, the significance of early low-grade posttransplant proteinuria remains uncertain. We analyzed the effect of proteinuria 3 months posttransplantation on death-censored graft loss, death with a functioning graft, vascular events within the graft's life, and estimated glomerular filtration rate at 5 years. Four hundred seventy-seven renal transplants from a single center (1988-2003) with a mean follow-up of 122 months were divided into four groups based on the median protein creatinine ratio (PCR) during the 3rd posttransplant month (PCR<0.15 [group 1, n=85]; PCR 0.15-0.5 [group 2, n=245]; PCR 0.5-1.00 [group 3, n=96]; PCR>1.00 [group 4, n=51]). Cox proportional hazards analysis was performed to study the impact of proteinuria on the various outcomes. Multivariate analysis revealed that even low-level proteinuria at 3 months predicted death-censored graft failure (group 1 [reference]--hazard ratio [HR]=1, group 2--HR=7.1, group 3--HR = 10.5, group 4--HR 16.0; P=0.001). The impact on death and the occurrence of vascular events was only significant for group 4 (HR: 2.6; P=0.01 for death and HR: 2.2; P=0.04 for va...Continue Reading

References

Oct 1, 1983·British Medical Journal·A B ShawJ D Lewis-Jackson
Jun 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C Burton, K P Harris
Jan 1, 1996·Journal of the American Society of Nephrology : JASN·B L KasiskeJ Z Ma
Nov 10, 1998·Journal of the American Society of Nephrology : JASN·D RushJ Jeffery
Apr 23, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·W F Keane, G Eknoyan
Jun 26, 1999·Clinical Transplantation·A YildizE Ark
Jun 26, 2002·Kidney International·Sundaram HariharanChristopher P Johnson
Mar 13, 2003·Kidney International·Kunitoshi IsekiShuichi Takishita
Jun 6, 2003·The New England Journal of Medicine·Eberhard Ritz
Nov 25, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Bruce KaplanHerwig-Ulf Meier-Kriesche
Dec 12, 2003·The New England Journal of Medicine·Brian J NankivellJeremy R Chapman
Jun 12, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gema Fernández-FresnedoM Arias
Jan 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Prakas Thomas D'CunhaK K Venkat
Jan 25, 2005·Transplantation·Bengt FellströmUNKNOWN Assessment of Lescol in Renal Transplantation Study Investigators
Aug 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Jean-Michel HalimiYvon Lebranchu
Aug 27, 2005·Journal of the American Society of Nephrology : JASN·Jeremy R ChapmanBrian J Nankivell
Nov 30, 2005·Transplantation·Emmanuel LetavernierChristophe Legendre
Jan 24, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L Straathof-GalemaL B Hilbrands
Jul 11, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M MyslakF G Cosio
Oct 13, 2006·Journal of the American Society of Nephrology : JASN·Mauro AbbateGiuseppe Remuzzi
Jan 16, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J-M HalimiY Lebranchu
Mar 3, 2007·Journal of the American Society of Nephrology : JASN·Bruce A PerkinsAndrzej S Krolewski
Oct 3, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D RushS Yilmaz
Oct 19, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H AmerF G Cosio
Oct 24, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Jean-Michel HalimiYvon Lebranchu
Feb 7, 2008·Clinical Journal of the American Society of Nephrology : CJASN·George L Bakris
Feb 26, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·F G CosioM D Stegall
Apr 11, 2008·Contributions to Nephrology·Stefan SchaubPeter Nickerson

❮ Previous
Next ❯

Citations

Jan 4, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jose Maria MoralesJesus Bustamante
Aug 18, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Romuald PanekBryce A Kiberd
Jan 7, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Shazia ShabirRichard Borrows
Aug 21, 2012·Transplantation Reviews·Julio PascualMarta Crespo
Dec 6, 2011·Transplantation Reviews·Asunción Sancho CalabuigDavid Ramos
Dec 6, 2011·Transplantation Reviews·Daniel SerónAngel Alonso
May 29, 2015·Transplantation·Asunción Sancho CalabuigLuis Manuel Pallardó Mateu
Apr 19, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Bertram L Kasiske
Jul 29, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M J ScianV Mas
May 24, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Claudio Ponticelli, Giorgio Graziani
Feb 5, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A CherukuriR J Baker
Jun 4, 2015·Transplantation Proceedings·O GuliyevM Haberal
Aug 28, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tomáš Seeman
Mar 15, 2015·Transplantation Proceedings·H SoyluN Seyahi
Aug 2, 2016·Transplantation·Dany AnglicheauPierre Marquet
Apr 25, 2017·Transplant International : Official Journal of the European Society for Organ Transplantation·Hege Kampen PihlstrømHallvard Holdaas
Aug 1, 2018·Transplant International : Official Journal of the European Society for Organ Transplantation·Manca OblakMiha Arnol
Jul 15, 2015·Journal of the American Society of Nephrology : JASN·Maarten NaesensDirk R J Kuypers

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
H AmerF G Cosio
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Jean-Michel HalimiYvon Lebranchu
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Jean-Michel HalimiYvon Lebranchu
Journal of the American Society of Nephrology : JASN
Hatem Amer, F G Cosio
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Gema Fernández-FresnedoManuel Arias
© 2021 Meta ULC. All rights reserved