PMID: 11929714Apr 4, 2002Paper

The clinical significance of GBV-C/HGV exposure in C-viral chronic liver disease and blood donors

Hepatology Research : the Official Journal of the Japan Society of Hepatology
Hiroshi SaitohYasuyuki Aarakawa

Abstract

Aims: The relationship between the hepatitis G virus (HGV) RNA-positive state or the HGV anti-E2 antibody-positive state, and various clinical parameters among patients with C-viral chronic liver disease and blood donors, was examined. Patients and methods: The subjects consisted of 166 patients with hepatitis C virus (HCV) RNA-positive liver disease, and 157 blood donors. Serum samples were tested for the presence of HGV RNA by the polymerase chain reaction method. The HGV E2 antibody level was measured with an enzyme-linked immunosorbent assay kit. Results: HGV RNA was detected in 1.3% of the blood donors, and HGV E2 antibodies were detected in the sera of 2.5% of the blood donors. The detection rate of HGV RNA and HGV E2 antibodies among the patients with C-viral liver disease was 4.8 and 28.3%, respectively. The detection rates of HGV RNA and HGV E2 antibody among those in each F stage were 0 and 25.0% among those in the F1 stage, 2.6 and 34.2% among those in F2, 11.1 and 27.8% among those in F3, 12.5 and 29.2% among those in F4, and 11.1 and 27.8% among those with hepatocellular carcinoma (HCC). The detection rate of HGV RNA increased with the progression of the F stage and HCC, however, the detection rate of HGV E2 antibo...Continue Reading

Citations

Dec 6, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Giovana Lotici Baggio-Zappia, Celso Francisco Hernandes Granato
Feb 6, 2009·The Journal of Physical Chemistry. B·Silvia Pérez-LópezConcepció Mestres
May 27, 2021·Reviews in Medical Virology·Joseph Zimmerman, Jason T Blackard
Dec 1, 2004·Langmuir : the ACS Journal of Surfaces and Colloids·Cristina LariosIsabel Haro

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