The clinical significance of sentinel lymph node micrometastasis in breast cancer

Breast Cancer Research and Treatment
Neill Patani, Kefah Mokbel

Abstract

The advent of sentinel lymph node biopsy (SLNB) and improvements in histopathological and molecular analysis have increased the rate at which micrometastases (MM) are identified. However, their significance has been the subject of much debate. In this article we review the literature concerning axillary lymph node (ALN) MM, with particular reference to SLNB. The controversies regarding histopathological assessment, clinical relevance and management implications are discussed. Literature review facilitated by Medline and PubMed databases. Published studies have reported divergent results regarding the significance and implications of ALN MM in general and sentinel lymph node (SLN) MM in particular. Some studies demonstrate no associations, whilst others have found these to be indicators of poor prognosis, associated with non-SLN involvement, in addition to local and distant failure. Absolute consensus regarding the optimal analytical technique for SLNs has yet to be reached, particularly concerning immunohistochemical (IHC) techniques targeting cytokeratins and the utility of contemporary molecular analysis. SLN MM are likely to represent an incremental detriment to prognosis and increased risk of non-SLN involvement, despite on...Continue Reading

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Citations

Feb 9, 2010·Breast Cancer Research and Treatment·Christoph HircheMichael Hünerbein
Aug 12, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Gang ChengAbass Alavi
Jul 27, 2011·Surgical Oncology·Mohamed SalhabKefah Mokbel
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Mar 16, 2021·Breast Cancer Research and Treatment·Madeleine HetterichAtanas Ignatov
Jun 6, 2009·Archives of Pathology & Laboratory Medicine·Aysegul A SahinKelly K Hunt

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