The clinical significance of thrombocytopenia in neonates with necrotizing enterocolitis

Journal of Pediatric Surgery
M VerveridisA Pierro

Abstract

The aim of this study was to evaluate the clinical significance of low platelet count in the surgical management of neonates with necrotizing enterocolitis (NEC). The clinical course of 58 consecutive neonates with advanced NEC (Bell's stages II or III) treated in the authors' hospital between 1995 and 1998 was reviewed. NEC in neonates who required operation was classified as isolated, multifocal, or pan-intestinal. Severe thrombocytopenia was defined as platelet count less than 100 x 10(9)/L. Rapid fall in platelet count was defined as fall greater than 150 x 10(9)/L within 24 hours to a level less than 100 x 10(9)/L. Median birth weight was 1,564 g (range, 550 to 4,270) and gestational age was 31 weeks (range 23 to 41). Twenty-two neonates (38%) were below 1,000 g. Age at the onset of the disease was 13 days (range, 1 to 62). NEC was treated medically in 7 neonates (12%). Indications for operation included pneumoperitoneum in 23 neonates (45%), clinical deterioration in 19 (37%), and intestinal obstruction in 9 (18%). The nadir platelet count (lowest level during the course of disease) was lower in patients with stage III disease than in patients with stage II disease (P <.05). The greater the extent of the disease, the lowe...Continue Reading

Citations

Apr 4, 2012·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Sheila M GephartMelissa D Halpern
Sep 27, 2008·Annual Review of Medicine·Marion C W Henry, R Lawrence Moss
Apr 9, 2010·Journal of Indian Association of Pediatric Surgeons·Mitul ParikhK L N Rao
Jan 15, 2013·ISRN Gastroenterology·Thomas Peter Fox, Charles Godavitarne
Nov 5, 2004·Journal of Perinatology : Official Journal of the California Perinatal Association·Alexander B KentonMary L Brandt
Dec 4, 2004·Journal of Perinatology : Official Journal of the California Perinatal Association·Alexander B KentonCaraciolo J Fernandes
Feb 27, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ravisha SrinivasjoisSanjay Patole
Sep 14, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Rhonnie SongAkhil Maheshwari
Nov 12, 2016·Seminars in Perinatology·Jamie R RobinsonMartin L Blakely
Mar 16, 2004·Journal of Pediatric Surgery·Renu SharmaBangalore R Premachandra
Feb 15, 2005·Early Human Development·Agostino Pierro
Nov 24, 2006·Journal of Perinatology : Official Journal of the California Perinatal Association·U KesslerS Berger
May 7, 2008·Pediatric Surgery International·Miguel Sáenz de Pipaón MarcosJosé Quero Jiménez
May 2, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Paolo ManzoniDaniele Farina
Oct 21, 2003·Journal of Perinatology : Official Journal of the California Perinatal Association·Pamela J Kling, John J Hutter
Jul 26, 2011·Journal of Clinical Laboratory Analysis·Zeynep ErasUğur Dilmen
Jul 16, 2003·Current Opinion in Infectious Diseases·Dimitris A KafetzisChristos Costalos
Aug 30, 2012·Pediatric Emergency Care·George SakellarisChristina Giannakopoulou
Apr 16, 2014·Indian Journal of Pediatrics·Banu AydınNurullah Okumuş
May 6, 2020·Proceedings of the National Academy of Sciences of the United States of America·Kopperuncholan NamachivayamAkhil Maheshwari
May 7, 2004·Hospital Medicine·Nigel Hall, Agostino Pierro
Jul 1, 2020·Pediatric Research·Akhil Maheshwari
Mar 28, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Parvesh Mohan GargVictoria Okhomina
Aug 8, 2015·Clinics in Perinatology·Akhil Maheshwari
May 24, 2020·American Journal of Perinatology·Moath M A AlhamadThao T B Ho
Dec 1, 2009·Journal of Pediatric Surgery·Nicholas EvennettSimon Eaton

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