Jun 4, 2019

The clinical spectrum of anti-MOG associated acquired demyelinating disorders: Three case-reports

Multiple Sclerosis and Related Disorders
A BellinviaM P Amato

Abstract

The spectrum of differential diagnosis of acquired demyelinating disorders of the central nervous system has been recently broadened. There is now growing evidence that supports anti-myelin oligodendrocyte antibodies associated demyelination as a distinct disease entity, with some clinical characteristics that somehow overlap those of Multiple Sclerosis (MS) and anti-AQP4+ Neuromyelitis Optica Spectrum Disorders (AQP4+NMOSD) but different pathogenesis and treatment strategies. We hereby present 3 cases of anti-MOG+ patients with different disease courses - ranging from mild to severe - all presenting with Optic neuritis (ON) at the onset. Optic neuritis (ON) is a common manifestation of different central nervous system (CNS) inflammatory disorders and can represent the first clinical event of MS and NMOSD. ON is also the most common presentation of antiMOG demyelinating disorders, followed by - and sometimes associated with - myelitis, most commonly extended over more than 2 spinal cord segments and defined as longitudinally extended transverse myelitis (LETM). All the three patients tested negative for oligoclonal bands in CSF and anti-AQP4 Ab in serum, had a relapsing disease course characterized by prominent involvement of t...Continue Reading

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Mentioned in this Paper

Treatment Protocols
Suspicion
Decision Making
Pathogenesis
Follow-up
Myelitis, Transverse
Inflammatory Disorder
Segment of Spinal Cord
Cerebrospinal Fluid
Differential Diagnosis

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