The clinical spectrum of cytomegalovirus colitis in adults

Alimentary Pharmacology & Therapeutics
Y EinbinderZ Ackerman

Abstract

Colonic cytomegalovirus reactivation rarely occurs in adults without inflammatory bowel disease or a known immunosuppressive state. To describe our experience with such patients. All consecutive admissions of patients with possible cytomegalovirus colitis, between 1995 and 2006, were reviewed retrospectively. Nineteen patients were studied. Most of the patients were elderly with multiple co-morbidities. Three main forms of disease presentation were recognized: acute diarrhoea, chronic diarrhoea and lower gastrointestinal bleeding. Colonic mucosal intranuclear inclusion bodies were found in 12 patients. Thirteen patients had cytomegalovirus viraemia (either by polymerase chain reaction and/or by white blood cell-cytomegalovirus antigenaemia test). Ganciclovir therapy was given to only eight patients; only five of these patients survived. The other subgroup of 11 patients received only supportive therapy. Most of the patients from this subgroup had a prolonged and complicated hospital course; only nine patients survived. Follow-up colonoscopies were performed only in five patients (out of the 14 patients who survived). In four of these patients, chronic mucosal inflammatory changes were noted. Cytomegalovirus colitis occurs rarel...Continue Reading

References

Oct 1, 1992·Journal of Diabetes and Its Complications·A N Bessman, F L Sapico
Dec 1, 1994·Journal of Clinical Gastroenterology·E V LoftusH A Carpenter
Nov 1, 1993·Annals of Internal Medicine·R W Goodgame
Jun 1, 1996·Digestive Diseases and Sciences·D L SchmuckerC K Daniels
Jan 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M EddlestonD A Warrell
Apr 14, 1999·The American Journal of Gastroenterology·R VegaM A Gassull
Feb 13, 2001·Kidney International. Supplement·M GirndtH Köhler
Mar 31, 2001·The American Journal of Gastroenterology·M CottoneL Pagliaro
Jul 27, 2001·The American Journal of Gastroenterology·K A PapadakisE A Vasiliauskas
Apr 26, 2003·Mechanisms of Ageing and Development·Anja Kristina Schröder, Lothar Rink
May 27, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pierre AbgueguenEric Pichard
Mar 9, 2004·Journal of Clinical Microbiology·Michael BoeckhLawrence Corey
Apr 24, 2004·The American Journal of Surgical Pathology·Neeraja KambhamTeri Longacre
Jan 14, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·V CriscuoliM Cottone
Apr 12, 2005·Nature Immunology·Tal I ArnonOfer Mandelboim
Apr 23, 2005·Digestive Diseases and Sciences·Polymnia GaliatsatosAndrew Szilagyi
May 17, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·G MaconiG Bianchi Porro
Jul 20, 2005·Heart & Lung : the Journal of Critical Care·Daniel S SiegalBurke A Cunha
Jan 20, 2006·Age and Ageing·M Rose LockwoodPanagiota Kitsanta
Sep 7, 2006·Inflammatory Bowel Diseases·Evangelia DimitrouliaAthanassios Tsakris
Oct 10, 2006·The American Journal of Gastroenterology·Ahmed Kandiel, Bret Lashner
Nov 16, 2006·World Journal of Gastroenterology : WJG·Dan CarterDavid Ezra
Dec 13, 2006·The American Journal of Gastroenterology·Katsuyoshi MatsuokaToshifumi Hibi

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Citations

Feb 19, 2010·Journal of Medical Virology·Yi-Hsuan LinHao-Tsai Cheng
Jul 16, 2014·Case Reports in Gastrointestinal Medicine·Emmanouil TelakisDimitrios Nikolakis
Dec 3, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jae-Hoon KoJae-Hoon Song
Oct 29, 2013·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Eung Jun LeeChan Sup Shim
May 1, 2012·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Cheal Wung HuhSang In Lee
May 25, 2021·Gastroenterology Clinics of North America·Jeffery L Meier

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