PMID: 2489231Dec 1, 1989Paper

The clinical spectrum of hypocalcaemia associated with bone metastases

Journal of Internal Medicine
J A RianchoJ González-Macías

Abstract

Malignancy-related hypocalcaemia has received less attention in the literature than the opposite perturbation, hypercalcaemia. Only, scarce and contradictory data exist about hypocalcaemia associated with bone metastases (BMH). We have reviewed the clinical records of 155 patients with bone metastases of solid tumours, 122 of which were followed during the whole course of the disease until death. The frequency of hypocalcaemia ranged from 5 to 13%, depending on the formula used to correct calcium values for protein concentration. BMH was almost exclusively limited to patients with osteoblastic metastases. The frequency of BMH among patients with prostate carcinoma was 13-27%, depending on the formula used. Only two of 60 patients with lytic bone lesions presented hypocalcaemia, and in both cases it was rather mild. The development of hypocalcaemia did not seem to imply a worse prognosis, at least in patients with carcinoma of the prostate. Thus, the prevalence of BMH appears to be higher than is usually considered. Adequate attention should be given to this disorder because of the potentially deleterious effects on several organ systems.

References

Jul 1, 1975·Metabolism: Clinical and Experimental·A B Schneider, L M Sherwood
Dec 1, 1988·Calcified Tissue International·S C KukrejaT E Lad
Oct 10, 1986·JAMA : the Journal of the American Medical Association·G P Zaloga, B Chernow
Jan 1, 1986·Acta Medica Scandinavica·C P Blomqvist
Oct 1, 1973·Archives of Internal Medicine·P RaskinT A Medsger
Dec 15, 1973·British Medical Journal·R B PayneJ R Milner
Jan 1, 1967·The British Journal of Nutrition·D GasterK Guggenheim
Dec 29, 1966·The New England Journal of Medicine·T C HallJ R Petranek
Dec 1, 1964·The Journal of Clinical Endocrinology and Metabolism·R E RANDALL, D S LIRENMAN
Jan 28, 1960·The New England Journal of Medicine·M A SACKNERL J BALIAN

❮ Previous
Next ❯

Citations

Jan 1, 1991·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·E D'ErasmoG F Mazzuoli
Apr 1, 1991·Postgraduate Medical Journal·J A RianchoJ González-Macías
Oct 29, 2013·Journal of Palliative Medicine·Hilda Alfaro RiverosJosep Planas Domingo
Feb 8, 2006·Nature Clinical Practice. Oncology·Sarah-Jane DawsonDanny Rischin
Aug 16, 2011·Journal of Intensive Care Medicine·Andrea Kelly, Michael A Levine
Mar 11, 2003·Prostate Cancer and Prostatic Diseases·G M OadesK W Colston
Nov 5, 1997·American Journal of Clinical Oncology·L I ChapP Rosen
Apr 9, 2010·Southern Medical Journal·Timothy CooksleyNaveed Younis
Nov 29, 2017·Der Internist·S Krug, P Michl
Jul 12, 2005·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Prabhat K Tandon, Ali A Rizvi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.