The clinical trial landscape in oncology and connectivity of somatic mutational profiles to targeted therapies

Human Genomics
Sara E PattersonSusan M Mockus

Abstract

Precision medicine in oncology relies on rapid associations between patient-specific variations and targeted therapeutic efficacy. Due to the advancement of genomic analysis, a vast literature characterizing cancer-associated molecular aberrations and relative therapeutic relevance has been published. However, data are not uniformly reported or readily available, and accessing relevant information in a clinically acceptable time-frame is a daunting proposition, hampering connections between patients and appropriate therapeutic options. One important therapeutic avenue for oncology patients is through clinical trials. Accordingly, a global view into the availability of targeted clinical trials would provide insight into strengths and weaknesses and potentially enable research focus. However, data regarding the landscape of clinical trials in oncology is not readily available, and as a result, a comprehensive understanding of clinical trial availability is difficult. To support clinical decision-making, we have developed a data loader and mapper that connects sequence information from oncology patients to data stored in an in-house database, the JAX Clinical Knowledgebase (JAX-CKB), which can be queried readily to access comprehe...Continue Reading

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Citations

Aug 10, 2016·Targeted Oncology·Cara M StatzSusan M Mockus
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Clinical Trials Mentioned

NCT01407198
NCT01396408

Software Mentioned

JAX Knowledgebase
JAX
Reflection
Tomcat
CKB
CGA
Gene Variant Curation
SnpSift
SnpEff
JAX Clinical Genome Analytics ( CGA )

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