The clinical use of biomarkers as prognostic factors in Ewing sarcoma.

Clinical Sarcoma Research
Annmeik M van MaldegemAndrew B Hassan

Abstract

Ewing Sarcoma is the second most common primary bone sarcoma with 900 new diagnoses per year in Europe (EU27). It has a poor survival rate in the face of metastatic disease, with no more than 10% survival of the 35% who develop recurrence. Despite the remaining majority having localised disease, approximately 30% still relapse and die despite salvage therapies. Prognostic factors may identify patients at higher risk that might require differential therapeutic interventions. Aside from phenotypic features, quantitative biomarkers based on biological measurements may help identify tumours that are more aggressive. We audited the research which has been done to identify prognostic biomarkers for Ewing sarcoma in the past 15 years. We identified 86 articles were identified using defined search criteria. A total of 11,625 patients were reported, although this number reflects reanalysis of several cohorts. For phenotypic markers, independent reports suggest that tumour size > 8 cm and the presence of metastasis appeared strong predictors of negative outcome. Good histological response (necrosis > 90%) after treatment appeared a significant predictor for a positive outcome. However, data proposing biological biomarkers for practical ...Continue Reading

References

Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P TerrierA Llombart-Bosch
Apr 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P PicciF Bertoni
Jun 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A W CraftD Pearson
Apr 29, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E de AlavaM Ladanyi
Sep 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M PaulussenH Jürgens
Apr 16, 1999·The Journal of Bone and Joint Surgery. British Volume·A AbuduR J Grimer
Aug 19, 1999·Genes, Chromosomes & Cancer·C M HattingerP F Ambros
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J P GinsbergF G Barr
Jan 7, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G BacciP Picci
Aug 22, 2000·Cancer·G WeiM Ladanyi
Aug 30, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S J CotterillA W Craft
Mar 10, 2001·Clinical Pharmacology and Therapeutics·UNKNOWN Biomarkers Definitions Working Group.
May 8, 2001·International Journal of Cancer. Journal International Du Cancer·H PavlakovicL Schweigerer
Jun 15, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·J A López-GuerreroA Llombart-Bosch
Aug 25, 2001·Archives of Pathology & Laboratory Medicine·A MaitraJ Geradts
Sep 25, 2001·Medical and Pediatric Oncology·R D JenkinH P Schultz
Jun 28, 2002·British Journal of Cancer·C M HattingerD R Betts
Mar 4, 2003·Archives of Surgery·Robert C G Martin, Murray F Brennan
Oct 11, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A OhaliR Zaizov
Feb 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tomoya MatsunobuYukihide Iwamoto
Feb 24, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bruno FuchsRalf Janknecht
Jun 24, 2004·British Journal of Cancer·C L WestonD Machin
Jul 22, 2004·Pediatric Blood & Cancer·Matthew J KrasinThomas E Merchant
Jan 22, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hsuan-Ying HuangMarc Ladanyi
May 26, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Katia ScotlandiMassimo Serra
Jul 27, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lisa M McShaneUNKNOWN Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics
Aug 18, 2005·British Journal of Cancer·L M McShaneUNKNOWN Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics
Oct 4, 2005·International Journal of Radiation Oncology, Biology, Physics·Trang H LaSuzanne L Wolden
Mar 7, 2006·Journal of Pediatric Surgery·Danko MikulićSven Seiwerth
Jul 11, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Michael KreuterRolf M Mesters
Jan 19, 2007·Journal of Pediatric Hematology/oncology·Guillermo De AnguloEugenie S Kleinerman
Aug 10, 2007·Journal of Cancer Research and Clinical Oncology·Kan YonemoriHirokazu Chuman
Oct 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Smadar AvigadIsaac Yaniv
Nov 14, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C Rodríguez-GalindoM J Krasin
Dec 7, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Irene Y CheungNai-Kong V Cheung
Dec 11, 2007·Virchows Archiv : an International Journal of Pathology·Cristina ZaniniFranco Turrini

❮ Previous
Next ❯

Citations

Feb 6, 2013·Clinical Sarcoma Research·Takeshi G KashimaNicholas A Athanasou
Jan 29, 2014·Cancer Chemotherapy and Pharmacology·Atif A AhmedLars Wagner
Jul 13, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M T MarinoK Scotlandi
Oct 12, 2012·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·B GreveH T Eich
Jul 21, 2015·International Journal of Molecular Sciences·Laurens G L SandPancras C W Hogendoorn
Jan 15, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Annemiek M van MaldegemHans Gelderblom
Oct 3, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L G L SandP C W Hogendoorn
Aug 24, 2013·Pediatric Blood & Cancer·Jeremy SharibSteven G DuBois
May 29, 2015·Journal of Pathology and Translational Medicine·Ki Yong NaYong-Koo Park
Feb 11, 2014·Human Pathology·Ki Yong NaYong-Koo Park
Oct 15, 2013·PloS One·Masanori TsugitaTakatoshi Ohno
Apr 12, 2017·Clinical Orthopaedics and Related Research·Rajpal NandraRobert Grimer
Jun 14, 2018·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Francisco GinerAntonio Llombart-Bosch
Jul 24, 2021·Journal of Hematology & Oncology·Richard MiallotPhilippe Naquet

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