The clinical use of P300 event related potentials for the evaluation of cholinesterase inhibitors treatment in demented patients

Journal of Neural Transmission
E A WerberJ M Rabey

Abstract

Centrally acting cholinesterase inhibitors (ChEIs) improve cognitive functions in Alzheimer's disease (AD) and other forms of dementia. Evaluation of treatment efficacy is based mainly on subjective assessment methods such as standardized neuropsychological tests. Therefore, an additional objective tool for the evaluation of drug response would be most helpful.Thirty-two patients suffering from dementia of several etiologies were treated with ChEIs (tacrine 19, donepezil 5, rivastigmine 8). Cognitive response was assessed pre ChEIs initiation (baseline) and after 26 weeks, as optimal tolerated doses were achieved and maintained (endpoint). Evaluation included repeated measurements of Mini Mental State Examination (MMSE), Alzheimer's disease assessment scale cognitive part (ADAS-cog) and P300. For statistical analysis we used ANOVA with repeated measures and Pearson correlation coefficient. Results demonstrated improvement of mean ADAS-cog by 2.0 points (from 29.4, n = 31 to 27.4, n = 29; p = 0.08) while MMSE remained almost unchanged (20.1, n = 29 to 19.8, n = 28). Mean P300 latency reduced significantly by 24 ms (from 383 +/- 7.9 msec, n = 32 to 359 +/- 7 msec, n = 32; p = 0.0001). However mean amplitudes did not change signif...Continue Reading

Citations

Dec 8, 2007·Nature Reviews. Drug Discovery·Daniel C JavittMihály Hajós
May 14, 2011·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Wilfried DimpfelMarian Verbruggen
Sep 17, 2010·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Zuzana KubováMiroslav Kuba
Jan 1, 2012·Expert Opinion on Medical Diagnostics·Vasilios K Kimiskidis, Vasileios T Papaliagkas
Oct 13, 2010·Biochemical Pharmacology·Steven C LeiserDavid M Devilbiss
Jun 2, 2011·International Journal of Alzheimer's Disease·Fabrizio Vecchio, Sara Määttä
Feb 3, 2009·Brain and Cognition·J A van DeursenW J Riedel
May 23, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Sami SchiffPiero Amodio
Jul 4, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Arūnas VaitkevičiusEglė Audronytė
Apr 1, 2015·European Journal of Pharmacology·Arjan BloklandAnke Sambeth
Jan 25, 2006·Neurobiology of Aging·Robert M ChapmanLindsey A Reilly
Dec 13, 2005·Biological Psychology·Brandon A AllyAndrew E Budson
Mar 23, 2006·Technology in Cancer Research & Treatment·Robert D PearlsteinPaul Haerich
Oct 14, 2004·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·N ColmanH Kaufmann
Sep 10, 2019·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Laure JacqueminAnnick Gilles
Feb 5, 2014·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Yu-San ChangChing-Kuan Liu
Dec 10, 2003·International Journal of Geriatric Psychiatry

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
C PaciL Curatola
Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Chiou-Lian LaiChing-Kuan Liu
© 2022 Meta ULC. All rights reserved