The clinical usefulness of 18F-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) in follow-up of curatively resected pancreatic cancer patients

HPB : the Official Journal of the International Hepato Pancreato Biliary Association
Woohyun JungSun-Whe Kim

Abstract

Computed tomography and serum tumor markers have limited value in detecting recurrence after curative surgery of pancreatic cancer. This study evaluated the clinical utility of 18F-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) in diagnosing recurrence. One hundred ten patients underwent curative resection of pancreatic cancer were enrolled. The diagnostic value of abdominal computed tomography (CT), PET-CT and serum carbohydrate antigen (CA) 19-9 concentration were compared. The prognostic value of SUVmax on PET-CT was evaluated. PET-CT showed relatively higher sensitivity (84.5% vs. 75.0%) and accuracy (84.5% vs. 74.5%) than CT, whereas PET-CT plus CT showed greater sensitivity (97.6%) and accuracy (90.0%) than either alone. In detecting distant recurrences, PET-CT showed higher sensitivity (83.1% vs. 67.7%) than CT. Nineteen patients showed recurrences only on PET-CT, with eleven having invisible or suspected benign lesions on CT, and eight had recurrences in areas not covered by CT. SUVmax over 3.3 was predictive of poor survival after recurrence. PET-CT in combination with CT improves the detection of recurrence. PET-CT was especially advantageous in detecting recurrences in areas not covered ...Continue Reading

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Citations

May 10, 2017·Bioconjugate Chemistry·Johoon KimDavid P Cormode
May 22, 2018·Nuclear Medicine Communications·Domenico AlbanoPierpaolo Alongi
Dec 5, 2017·Abdominal Radiology·S JavadiE P Tamm
Jun 22, 2021·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·UNKNOWN Committee of the Korean clinical practice guideline for pancreatic cancer and National Cancer Center, Korea

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