The Clinical Utility of Cell-Free DNA Measurement in Differentiated Thyroid Cancer: A Systematic Review

Frontiers in Oncology
Jonathan M FusseyHisham Mehanna

Abstract

Cell-free DNA (cfDNA) can be detected in the circulation of healthy individuals, but is found in higher concentrations in cancer patients. Furthermore, mutations in tumor cells can be identified in circulating DNA fragments. This has been the subject of significant interest in the field of cancer research, but little has been published in thyroid cancer. To assess all available evidence on the use of circulating cfDNA in the diagnosis, management and surveillance of patients with differentiated thyroid cancer, and collate it into a systematic review to guide future research. A comprehensive literature search on the measurement of cfDNA in thyroid cancer was undertaken, and results from relevant studies collated into a systematic review. Nine studies were identified, with varying methodologies and findings. Key techniques and findings are summarized. There is limited but promising evidence that somatic mutations in thyroid cancer can be detected in circulating cfDNA and are associated with more advanced disease. Further research is required to develop a clinically useful tool based on cfDNA to improve the management of thyroid cancers.

References

Sep 22, 2005·The Journal of Clinical Endocrinology and Metabolism·Mingzhao XingPaul W Ladenson
Nov 3, 2005·The Journal of Clinical Endocrinology and Metabolism·Shuiying HuMingzhao Xing
Jun 21, 2006·Human Pathology·Vítor TroviscoManuel Sobrinho-Simões
Apr 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Masaru ShinozakiDave S B Hoon
Dec 20, 2007·Expert Review of Molecular Diagnostics·Marina N Nikiforova, Yuri E Nikiforov
Aug 13, 2008·DNA and Cell Biology·Raquel CatarinoRui Medeiros
Oct 24, 2009·The Journal of Clinical Endocrinology and Metabolism·Kendall W CradicStefan K G Grebe
May 13, 2011·Nature Reviews. Cancer·Heidi SchwarzenbachKlaus Pantel
Oct 19, 2011·Annals of Internal Medicine·Penny F WhitingUNKNOWN QUADAS-2 Group
Oct 12, 2012·The Journal of Clinical Endocrinology and Metabolism·Carol LiMartha A Zeiger
Mar 15, 2013·The New England Journal of Medicine·Sarah-Jane DawsonNitzan Rosenfeld
Jun 22, 2013·The Journal of Clinical Endocrinology and Metabolism·C PupilliG Forti
Aug 13, 2013·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mariangela ZaneMaria Rosa Pelizzo
Aug 29, 2013·BMJ : British Medical Journal·Juan P BritoVictor M Montori
Feb 21, 2014·Science Translational Medicine·Chetan BettegowdaLuis A Diaz
Jul 6, 2014·Clinical Endocrinology·Petros PerrosUNKNOWN British Thyroid Association
Oct 17, 2014·Molecular Cancer Therapeutics·David J PankaRyan J Sullivan
Nov 25, 2014·Cell·UNKNOWN Cancer Genome Atlas Research Network
Apr 9, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J TieP Gibbs
May 20, 2015·Frontiers in Molecular Biosciences·Kristina Warton, Goli Samimi
Dec 21, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daniel PietraszJean-Baptiste Bachet
Jul 5, 2017·International Journal of Molecular Sciences·Francesca SalviantiPamela Pinzani

❮ Previous
Next ❯

Citations

Jul 20, 2019·Endocrine Reviews·Maria E CabanillasCamilo Jimenez
Feb 11, 2020·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Katherine A AraqueJoanna Klubo-Gwiezdzinska
Jan 31, 2020·Frontiers in Oncology·Hannah AlmubarakBedri Karakas
Mar 8, 2019·International Journal of Molecular Sciences·Germana RappaAurelio Lorico
Feb 19, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Aliaa M HigaziRagaa A Matta
Jul 25, 2021·International Journal of Molecular Sciences·Chiara RomanoLivia Manzella

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques
PCR
biopsy
blood draw

Software Mentioned

Excel

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Translational Research : the Journal of Laboratory and Clinical Medicine
Jessica A HowellRohini Sharma
Biochimica Et Biophysica Acta
Jenna VanLiere Canzoniero, Ben Ho Park
© 2022 Meta ULC. All rights reserved