The Clinical Utility of miR-21 and let-7 in Non-small Cell Lung Cancer (NSCLC). A Systematic Review and Meta-Analysis

Frontiers in Oncology
Cecilia Pop-BicaIoana Berindan-Neagoe

Abstract

Non-small cell lung cancer (NSCLC) remains a problem worldwide due to its rapid progression and low rate of response to treatment. The heterogeneity of these tumors observed in histopathology exam but also in the mutational status and gene expression pattern makes this malignancy difficult to treat in clinic. The present study investigated the effect of miR-21 and let-7 family members as prognostic biomarkers in NSCLC patients based on the results published in different studies regarding this subject until March 2019. The analysis revealed that these two transcripts are steady biomarkers for prediction of patient outcome or survival. Upregulated expression of miR-21 is associated with poor outcome of patients with NSCLC [HR = 1.87, 95% CI = (1.41, 2.47), p < 0.001]. The analysis regarding let-7 family, specifically let-7a/b/e/f, revealed that downregulated expression of these transcripts predicts poor outcome for NSCLC patients [HR = 2.61, 95% CI = (1.58, 4.30), p < 0.001]. Besides, the reliability of these microRNAs is reflected in the fact that their prognostic significance is constant given the different sample types (tissue, FFPE tissue, serum, serum/plasma or exosomes) used in the selected studies.

References

Apr 22, 2005·The New England Journal of Medicine·George Adrian CalinCarlo M Croce
Mar 15, 2006·Cancer Cell·Nozomu YanaiharaCurtis C Harris
Nov 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D Neil HayesMatthew Meyerson
Apr 18, 2007·Genes & Development·Yong Sun Lee, Anindya Dutta
Mar 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·Madhu S KumarTyler Jacks
Mar 18, 2008·Cell Cycle·Aurora Esquela-KerscherFrank J Slack
May 3, 2008·Mayo Clinic Proceedings·Julian R MolinaAlex A Adjei
May 26, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alberto IzzottiSilvio De Flora
Jul 15, 2009·Proceedings of the National Academy of Sciences of the United States of America·Masahiro SeikeCurtis C Harris
Dec 17, 2009·Journal of Experimental & Clinical Cancer Research : CR·Jun WanGenfa Shan
Jan 14, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Maria Teresa LandiEna Wang
Feb 23, 2010·International Journal of Surgery·David MoherUNKNOWN PRISMA Group
May 29, 2010·Journal of Cancer Research and Clinical Oncology·Wen GaoYongqian Shu
Jul 21, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matthew D WilkersonD Neil Hayes
Oct 6, 2010·Advances in Genetics·Muller Fabbri, George A Calin
Feb 26, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Motonobu SaitoCurtis C Harris
Apr 30, 2011·Clinical Science·Reinhold Munker, George A Calin
Jul 2, 2011·Journal of Surgical Oncology·Zhao-Xia WangWei De
May 24, 2012·Journal of Cancer Research and Clinical Oncology·Yong-Kui ZhangXiao-Guang Liu
Sep 11, 2012·Nature·UNKNOWN Cancer Genome Atlas Research Network
Jun 20, 2013·Radiation Oncology·Xiao-chun WangJian-Chao Luo
Nov 1, 2013·Nature Reviews. Drug Discovery·Hui LingGeorge A Calin
Jan 1, 2012·MicroRNA·Jen-Liang SuMin-Liang Kuo
Aug 1, 2014·Nature·UNKNOWN Cancer Genome Atlas Research Network
Dec 17, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ioana Berindan-Neagoe, George A Calin
Aug 21, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisAndrew G Nicholson
Nov 12, 2015·Pharmacogenomics·Cristina Pérez-RamírezMiguel Ángel Calleja-Hernández

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Citations

Mar 21, 2021·Molecular Cancer·Parvez KhanMohd Wasim Nasser

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