Abstract
To study the dynamic change of hepatocyte growth factor after hepatectomy in patients with primary liver cancer, and to analyse the prognostic value of hepatocyte growth factor and c-met for these patients. Thirty-one consecutive patients undergoing partial hepatectomy for liver cancer were studied. Serum hepatocyte growth factor level was determined by using enzyme-linked immunosorbent assay kit before and after operation, respectively. C-met protein and MRNA expressions in cancerous and paracancerous tissues were examined by immunohistochemical and RT-PCR methods, respectively. The correlations between clinical-pathologic parameters and the expressions of hepatocyte growth factor in serum and c-met in cancerous tissues were analysed, respectively. Liver cancer patients had a significantly higher level of serum hepatocyte growth factor than normal controls (1.0424+/-0.498 ng/ml versus 0.685+/-0.115 ng/ml, p=0.008). Serum hepatocyte growth factor level was positively affected by tumour size, node cirrhosis, portal vein tumour thrombi, cholangiocarcinoma (including combined hepatocellular carcinoma), poorly differentiated hepatocellular carcinoma and tumour recurrence or metastases. After hepatectomy, serum hepatocyte growth fac...Continue Reading
References
Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·G HartmannW Birchmeier
Jul 31, 1992·Biochemical and Biophysical Research Communications·S KonoT Nakamura
Oct 1, 1992·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·S GiordanoP M Comoglio
Apr 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P M LindroosG K Michalopoulos
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·K M WeidnerY Daikuhara
Feb 15, 1991·Science·D P BottaroS A Aaronson
Jan 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G ShiotaT Nakamura
Apr 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T UekiE Okamoto
Aug 24, 1999·Transplantation Proceedings·F J ShihC J Lee
Feb 27, 2001·Intervirology·H YamagamiY Arakawa
May 31, 2001·The Journal of Cell Biology·R WangJ M Bishop
Aug 31, 2001·Biochemical and Biophysical Research Communications·Y JiangX Yang
Feb 7, 2002·Blood·Patrick W B DerksenSteven T Pals
Mar 16, 2002·Oncogene·Norio HoriguchiMasatomo Mori
Oct 31, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·K Okuda
Jan 7, 2004·Circulation·Munehisa ShimamuraRyuichi Morishita
Apr 10, 2004·Cancer Science·Takeshi KubotaHisakazu Yamagishi
Jul 21, 2004·Life Sciences·Makoto TaniguchiKenzo Sato
Aug 4, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·Thorsten CramerHermann Herbst
Aug 4, 2004·Journal of Hepatology·Si Y WangXiaoming Yang
Aug 31, 2004·World Journal of Gastroenterology : WJG·Yong HeHai-Min Li
Dec 14, 2004·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Akio IdoHirohito Tsubouchi
Feb 26, 2005·Radiology·Ping LiangQiujin Xiao
Oct 26, 2005·Journal of Gastroenterology and Hepatology·Satoru HasuikeHirohito Tsubouchi
Citations
Feb 5, 2014·Future Oncology·Lorenzo FornaroGianluca Masi
Nov 26, 2013·Digestive Diseases and Sciences·Yong XuRong Liu
Aug 1, 2013·Clinical & Experimental Metastasis·Nadia HarunC Christophi
Jun 14, 2008·Expert Opinion on Investigational Drugs·Xiangdong LiuPeggy A Scherle
May 15, 2012·Biochemical and Biophysical Research Communications·Kriengsak LirdprapamongkolJisnuson Svasti
Jan 16, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G-Y ChauC-W Wu
Jun 12, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Hussein M AttaOlfat A Hammam
May 15, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Fu-Sheng WuWei Wu
Sep 3, 2010·Journal of Surgical Oncology·Omar BarakatDavid A Engler
Sep 29, 2017·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Scott M ThompsonDavid A Woodrum
Nov 4, 2017·Nuclear Medicine Communications·Koichi YanoToshinori Hirai
May 9, 2012·Nature Reviews. Clinical Oncology·Solange Peters, Alex A Adjei
Oct 27, 2018·International Journal of Molecular Sciences·Hongli ZhangYan-Dong Wang
Jan 13, 2017·Oncotarget·Massimiliano BerrettaVincenzo Canzonieri
Mar 26, 2016·Oncotarget·Yanni ZhangMingqiang Zhang
Apr 14, 2016·Journal of Clinical Pathology·Ana Belen Fajardo-PuertaLong R Jiao
Feb 23, 2019·Autophagy·Xing HuangWei Xie
Sep 14, 2013·Oncotarget·Niraj M ShahDavid J MacEwan
Jan 12, 2017·Oncology Reports·Feng GaoMing Li
Aug 21, 2019·Frontiers in Oncology·Yilan MaZheng Liu
Jun 13, 2019·Oncology Letters·Hyung-Wook Chun, Ran Hong
Dec 1, 2019·Cancer Science·Rui ZhangJinhong Chen
May 20, 2016·Molecular Cancer Therapeutics·Zhiqiang DuMingqiang Zhang
Oct 8, 2009·Cancer Research·Fawn QianAlison H Joly
Feb 8, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lipika GoyalAndrew X Zhu
Feb 22, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ning ZhengJichuang Wang
Oct 6, 2018·Gastroenterology·Tim F GretenKevin F Staveley-O'Carroll
Jun 20, 2021·Oncogene·Jianjiang FuJuan Peng