The clinical value of prostate-specific antigen and bone scintigraphy in the staging of patients with newly diagnosed, pathologically proven prostate cancer

European Journal of Nuclear Medicine
M RudoniE Inglese

Abstract

Recent reports suggest that radionuclide bone scan (BS) may not be necessary in the standard staging evaluation of patients with prostate cancer when serum prostate-specific antigen (PSA) levels are normal. To evaluate the ability of PSA to predict BS findings, we retrospectively reviewed the case records of 118 consecutive patients (median age 73 years, range 50-90 years) with newly diagnosed, untreated, pathologically proven prostate cancer who underwent BS and serum PSA sampling within a period of no more than 3 months. Fifty-four out of 118 BSs demonstrated metastatic bone disease. A PSA value of less than 10 ng/ml excluded bone metastasis; of 35 patients with a serum PSA level of 20 ng/ml or less, seven had a positive BS (negative predictive value of 80%). These findings provide additional confirmation of the value of low serum PSA concentrations in excluding the need for a staging BS, although the threshold for a high value of negative predictive accuracy is lower than previously reported.

References

May 1, 1978·British Journal of Urology·E P O'DonoghueG D Chisholm
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·S E SchildL M Frick
Jan 1, 1992·European Urology·P F MuldersF M Debruyne
Aug 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M A RitterT J Kinsella
Sep 1, 1992·British Journal of Urology·M L PantelidesN J George
Jan 1, 1988·American Journal of Clinical Oncology·F FinckerJ Pasquier
Oct 1, 1989·Clinical Nuclear Medicine·W J ShihU Y Ryo
Jan 6, 1993·JAMA : the Journal of the American Medical Association·J E OesterlingF C Lowe
Jun 1, 1993·Disease Markers·J H Howanitz

❮ Previous
Next ❯

Citations

Jun 1, 1996·Urology·A E KatzR Buttyan
Dec 19, 2003·The Urologic Clinics of North America·Joel B Nelson, Herbert Lepor
Dec 21, 2000·International Journal of Radiation Oncology, Biology, Physics·N LeeR D Ennis
Oct 30, 2008·Asian Journal of Andrology·Raj P PalMasood A Khan
Jul 30, 2011·The Urologic Clinics of North America·Reginald W DusingPeter Van Veldhuizen
Dec 16, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Martin HetzelHolger Schirrmeister
Feb 17, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Nathan LawrentschukAndrew M Scott
May 6, 2004·The Journal of Urology·Sadeq AbuzalloufHimu Lukka
Feb 28, 1998·The Orthopedic Clinics of North America·K J Donohoe
Jun 28, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Christopher Chee Kong HoAzad H A Razack
Jun 4, 2002·Pharmacogenetics·Torbjörn SöderströmAnders Rane
Apr 1, 1997·Seminars in Nuclear Medicine·A Z KrasnowA T Isitman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.