Abstract
Overexpression of Vav3, a gene involved in signal transduction, promotes invasion and inhibits apoptosis in several cancers. The clinical value of the protein product of this gene, Vav3, in the peripheral blood of gastric cancer patients is unknown. We hypothesised increased serum Vav3 that related to tissue levels and lymph node metastases. In addition, we further explored its clinical value in respect of linked molecules Rac-1, MMP-7 and ICAM-1 Methods: 120 gastric cancer patients who had radical surgery were enrolled. Immunohistochemistry was used to determine the expressions of Vav3, Rac-1, MMP-7 and ICAM-1 in gastric cancer mucosa and normal mucosa. ELISA was used to detect these proteins in peripheral blood of gastric cancer patients and 100 age- and sex-matched healthy controls. Vav3, Rac-1 and MMP-7 (P < 0.001), but not ICAM-1 (P = 0.303) were more highly expressed by cancer tissues than normal gastric mucosa. Serum levels of all molecules were higher than those in healthy subjects (P < 0.001). Levels of Vav3, Rac-1 and MMP-7 decreased 2 weeks postoperatively (all P < 0.001) but there was no change in ICAM-1 (P = 0.192). Similarly, increased levels of Vav3, Rac-1 and MMP-7 were present in patients with lymphatic metasta...Continue Reading
References
Jun 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bin WeiChristopher E Rudd
Jun 4, 2008·BMC Cancer·Kiwon LeeShan Lu
Jan 30, 2010·The Journal of Biological Chemistry·Beatriz Del Valle-PérezFrancesc Viñals
Mar 2, 2010·Cell Adhesion & Migration·Pedro M Fernandez-Salguero
Sep 2, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Carly F HaleChristopher W Cowan
Dec 15, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ching-Hao LiJaw-Jou Kang
Apr 19, 2012·Blood·Marion TravertPhilippe Gaulard
Jun 5, 2012·Cancer Research·Kai-Ti LinLu-Hai Wang
Oct 2, 2012·Molecular Endocrinology·Stephanie O PeacockKerry L Burnstein
Feb 14, 2013·Urologic Oncology·Kenichi HiraiHiromitsu Mimata
Apr 10, 2013·Molecular Cancer·Takeo NomuraHiromitsu Mimata
May 18, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Xi-Wen Zhu, Jian-Ping Gong
Aug 13, 2013·Cell Metabolism·Mauricio Menacho-MárquezXosé R Bustelo
Aug 13, 2013·PLoS Biology·Robin Mejia
Sep 28, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Bibo TanYü Liu
Feb 12, 2014·Molecular Biology Reports·Yong LiDong Wang
Jun 3, 2014·Breast Cancer Research : BCR·Helena AguilarMiguel Angel Pujana
Nov 29, 2014·Cancer Gene Therapy·B TanX Zhao
Dec 24, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Bi-Bo TanDong Wang
Feb 16, 2016·Oncogene·L G AhronianB C Lewis
Mar 10, 2016·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Ying SunXian-Dong Li
Mar 15, 2016·Scientific Reports·Ming LiYinping Lin
Mar 22, 2016·Oncology Letters·K E ZhangQiang-Xiu Wang
May 22, 2016·Carcinogenesis·Abhishek DhawanMartin Bornhäuser
Jun 9, 2016·Biochemical and Biophysical Research Communications·Bohee JangEok-Soo Oh
Jun 29, 2016·Cell Biochemistry and Biophysics·X Y Xiao, X P Lang