The clinicopathological factors associated with prognosis of patients with resectable perihilar cholangiocarcinoma: A systematic review and meta-analysis

Medicine
Zengwei TangXun Li

Abstract

The refinement in surgical techniques combined with the preoperative management has improved the resectability rate of perihilar cholangiocarcinoma (pCCA). However, the prognosis of pCCA with curative resection is still dismal. This meta-analysis was performed to investigate the prognostic clinicopathological factors in resectable pCCA.PubMed, the Cochran Library, ScienceDirect, and Web of Science were searched systematically to identify reports focusing on studying the prognostic clinicopathological factors in resectable pCCA. The hazard ratios (HRs) and its 95% confidence interval (95%CI) from the identified studies using Cox proportional hazard regression model were extracted for overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS) analysis.Three prospective and 35 retrospective cohort studies including 5681 resectable pCCA were included in the pooled analysis. Among more than 20 clinicopathological factors associated with negative survival of pCCA, only 6 were included in quantitative analysis which showed that lymph node involvement was associated with a reduced OS (HR = 2.04; 95%CI: 2.10-2.62), DSS (HR = 1.80; 95%CI: 1.39-2.34), DFS (HR = 4.38; 95%CI: 1.89-10.14), negative resection marg...Continue Reading

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Citations

Oct 3, 2020·Journal of Clinical Medicine·Hans-Michael HauDaniel Seehofer
Dec 12, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Huan QinZhiyu Chen
Nov 5, 2020·World Journal of Surgical Oncology·Joachim GeersBaki Topal
Feb 26, 2021·Therapeutic Advances in Gastrointestinal Endoscopy·Lei LiangTian Yang
Jun 3, 2021·Journal of Clinical Medicine·Guergana PanayotovaKeri E Lunsford
Jun 3, 2021·Langenbeck's Archives of Surgery·Christian BenzingJohann Pratschke
Aug 8, 2021·Cancers·Andrea LauterioLuciano De Carlis
Sep 3, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Kyubo KimEui Kyu Chie
Mar 13, 2021·Visceral Medicine·Lynn E NooijenJoris I Erdmann
Nov 17, 2021·Virchows Archiv : an International Journal of Pathology·Melroy A D'SouzaChristian Sturesson

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Methods Mentioned

BETA
surgical resection
dissection

Software Mentioned

Stata
Meta
- Analysis of Observational Studies in Epidemiology MOOSE
GraphPad Prism
MP

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