The clinicopathological significance and potential drug target of E-cadherin in NSCLC

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Kaize ZhongJian Zhao

Abstract

Human epithelial cadherin (E-cadherin), a member of transmembrane glycoprotein family, encoded by the E-cadherin gene, plays a key role in cell-cell adhesion, adherent junction in normal epithelial tissues, contributing to tissue differentiation and homeostasis. Although previous studies indicated that inactivation of the E-cadherin is mainly induced by hypermethylation of E-cadherin gene, evidence concerning E-cadherin hypermethylation in the carcinogenesis and development of non-small cell lung carcinoma (NSCLC) remains controversial. In this study, we conducted a meta-analysis to quantitatively evaluate the effects of E-cadherin hypermethylation on the incidence and clinicopathological characteristics of NSCLC. A comprehensive search of PubMed and Embase databases was performed up to October 2014. Analyses of pooled data were performed. Odds ratios (ORs) were calculated and summarized. Our meta-analysis combining 18 published articles demonstrated that the hypermethylation frequencies in NSCLC were significantly higher than those in normal control tissues, OR = 3.55, 95 % confidence interval (CI) = 1.98-6.36, p < 0.0001. Further analysis showed that E-cadherin hypermethylation was not strongly associated with the sex or smok...Continue Reading

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Citations

Jan 29, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ling WeiXian-Rang Song
Sep 24, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Huanzhang ShaoWenbin Lu
Jul 2, 2020·International Journal of Molecular Sciences·Victoria SarneRita Seeboeck
Aug 22, 2017·NPJ Precision Oncology·Fenil ShahMark R Kelley

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