The clock genes Period 2 and Cryptochrome 2 differentially balance bone formation.

PloS One
Erik MarondeU Albrecht

Abstract

Clock genes and their protein products regulate circadian rhythms in mammals but have also been implicated in various physiological processes, including bone formation. Osteoblasts build new mineralized bone whereas osteoclasts degrade it thereby balancing bone formation. To evaluate the contribution of clock components in this process, we investigated mice mutant in clock genes for a bone volume phenotype. We found that Per2(Brdm1) mutant mice as well as mice lacking Cry2(-/-) displayed significantly increased bone volume at 12 weeks of age, when bone turnover is high. Per2(Brdm1) mutant mice showed alterations in parameters specific for osteoblasts whereas mice lacking Cry2(-/-) displayed changes in osteoclast specific parameters. Interestingly, inactivation of both Per2 and Cry2 genes leads to normal bone volume as observed in wild type animals. Importantly, osteoclast parameters affected due to the lack of Cry2, remained at the level seen in the Cry2(-/-) mutants despite the simultaneous inactivation of Per2. This indicates that Cry2 and Per2 affect distinct pathways in the regulation of bone volume with Cry2 influencing mostly the osteoclastic cellular component of bone and Per2 acting on osteoblast parameters.

References

Sep 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C C Liu, D N Kalu
Dec 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A M ParfittR R Recker
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·D A CorralG Karsenty
Aug 10, 1999·Nature·T S Zheng, R A Flavell
May 12, 2000·Science·L P ShearmanS M Reppert
Aug 29, 2002·Nature·Steven M Reppert, David R Weaver
Oct 17, 2002·Genes & Development·Henrik OsterUrs Albrecht
Feb 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Seung-Hee YooJoseph S Takahashi
Sep 7, 2005·Cell·Loning FuGerard Karsenty
Mar 1, 2006·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Robert DallmannStephan Steinlechner
Oct 24, 2006·Current Biology : CB·Céline A FeilletEtienne Challet
Dec 6, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sanjin ZvonicJeffrey M Gimble
Apr 4, 2007·Circulation·Hema ViswambharanZhihong Yang
Jul 10, 2007·Nature Medicine·Mone Zaidi
Aug 24, 2007·Current Biology : CB·Martha Merrow, Till Roenneberg
Sep 18, 2007·Nature Medicine·Shingo SatoShu Takeda
Jan 8, 2008·Cell Metabolism·Clifford J Rosen
Jan 9, 2008·Rapid Communications in Mass Spectrometry : RCM·Thomas J-C VincentCatherine M Lange
Mar 13, 2008·Physiological Genomics·Elin GrundbergTomi Pastinen
Mar 28, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Violetta Pilorz, Stephan Steinlechner
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·U AlbrechtJ Ripperger
May 10, 2008·The Journal of Clinical Investigation·Sergio VairaDeborah Veis Novack
Sep 13, 2008·Current Biology : CB·Michael H HastingsJohn S O'Neill
Oct 30, 2008·Calcified Tissue International·Anita Vibsig Neutzsky-WulffKim Henriksen
Apr 7, 2009·Bone·Kim HenriksenMorten A Karsdal
Apr 23, 2009·Journal of Cellular Biochemistry·Jeffrey M GimbleBruce A Bunnell
Jun 23, 2011·Experimental Biology and Medicine·Gi-Yeon HanChan-Wha Kim

❮ Previous
Next ❯

Citations

Mar 4, 2014·Experimental Cell Research·Li ZhengPetros Papagerakis
Mar 15, 2013·Bone·Li ZhengPetros Papagerakis
Dec 27, 2015·Life Sciences·Jerry Vriend, Russel J Reiter
Mar 1, 2011·FEBS Letters·Jürgen A RippergerUrs Albrecht
Dec 2, 2015·Climacteric : the Journal of the International Menopause Society·J KimJ G Kim
Jan 26, 2016·Medical Hypotheses·Michael G GraySusan G Hurley
Oct 22, 2015·The Journal of Physiology·Elizabeth A SchroderKaryn A Esser
Mar 2, 2016·Scientific Reports·Tatsuya KunimotoKazuhiro Yagita
Aug 20, 2015·Computational and Structural Biotechnology Journal·Luise FuhrAngela Relógio
Jun 6, 2014·Scientific Reports·Ching-Yan Chloé YeungQing-Jun Meng
Jun 7, 2013·Arthritis and Rheumatism·Francis Berenbaum
Mar 19, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·John-David P McElderryMichael D Morris
Nov 14, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y LiY Hong
Feb 3, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Christine M SwansonEric S Orwoll
Jan 21, 2015·Journal of Internal Medicine·C Dibner, U Schibler
Sep 10, 2014·The Biochemical Journal·Michal Dudek, Qing-Jun Meng
Jun 6, 2014·Annals of Medicine·Nicole M KettnerLoning Fu
Dec 24, 2011·PLoS Computational Biology·Angela RelógioHanspeter Herzel
Jun 17, 2016·Nature Reviews. Rheumatology·Francis Berenbaum, Qing-Jun Meng
May 3, 2018·Physiological Reviews·Florent Elefteriou
Jul 5, 2017·Biochemical Society Transactions·Minnie Fu, Xiaoyong Yang
Apr 9, 2019·Endocrine-related Cancer·Anna AngelousiGeorge P Chrousos
Aug 26, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C M SwansonO M Buxton
Sep 1, 2018·Endocrine Reviews·Pureum KimOliver Rawashdeh
Feb 15, 2019·BMC Oral Health·Klara Janjić, Hermann Agis
Jun 14, 2016·The Journal of Clinical Endocrinology and Metabolism·Jean RedmondInez Schoenmakers
Jul 27, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C SwansonO M Buxton
Nov 18, 2018·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Qian-Yuan WuFeng-Lai Yuan
Apr 14, 2020·Journal of Cellular and Molecular Medicine·Lisanne GrünherzArndt Friedrich Schilling
Aug 26, 2016·Journal of Biological Rhythms·Nan Yang, Qing-Jun Meng
Jul 17, 2020·International Journal of Molecular Sciences·Ellen OttoJohannes Keller

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
ELISA

Software Mentioned

Measure
MathLab
COSINOR
Osteo

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.