The Cloning and Expression of Human Monoclonal Antibodies: Implications for Allergen Immunotherapy

Current Allergy and Asthma Reports
Louisa K James

Abstract

Allergic responses are dependent on the highly specific effector functions of IgE antibodies. Conversely, antibodies that block the activity of IgE can mediate tolerance to allergen. Technologies that harness the unparalleled specificity of antibody responses have revolutionized the way that we diagnose and treat human disease. This area of research continues to advance at a rapid pace and has had a significant impact on our understanding of allergic disease. This review will present an overview of humoral responses and provide an up-to-date summary of technologies used in the generation of human monoclonal antibodies. The impact that monoclonal antibodies have on allergic disease will be discussed, with a particular focus on allergen immunotherapy, which remains the only form of treatment that can modulate the underlying immune mechanisms and induce long-term clinical tolerance.

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Citations

Mar 1, 2019·Current Allergy and Asthma Reports·Geoffrey A MuellerLars C Pedersen
May 3, 2019·Autism : the International Journal of Research and Practice·Marisa ViljoenPetrus J de Vries
Oct 30, 2020·Frontiers in Immunology·Sabine FlickerSergei V Tillib
Sep 4, 2020·Allergy·Öykü ÜzülmezHeimo Breiteneder

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Methods Mentioned

BETA
transgenic
phage display
PCR
flow cytometry
chemical modification
X-ray
nuclear magnetic resonance

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