PMID: 9533612Apr 9, 1998Paper

The co-existence of insulin-mediated decreased mean arterial pressure and increased sympathetic nerve activity is not mediated by the baroreceptor reflex and differentially by hypoglycemia

Clinical and Experimental Hypertension : CHE
H LuJ C Dunbar

Abstract

In this study we measured simultaneously and sequentially the lumbar sympathetic nerve activity (LSNA) or renal sympathetic nerve activity (RSNA), mean arterial pressure (MAP), and heart rate (HR) in response to insulin with co-existing hypoglycemia or with glucose replacement in normal rats. Sinoaortic denervation (SAD) was used to evaluate the influence of the baroreflex. LSNA, RSNA, MAP and HR were determined using an acquisition processor and computer software. Bolus insulin infusion where the blood glucose was allowed to decrease resulted in an immediate decrease in MAP. The HR decreased for approximately 15 min and subsequently increased. The LSNA increased immediately after insulin infusion peaking at 25 minutes and then recovered toward baseline. Insulin infusion with glucose replacement resulted in a decrease in MAP and HR. The LSNA progressively increased and was maintained throughout the experimental period. Insulin infusion with hypoglycemia increased RSNA and when hypoglycemia was prevented the RSNA decreased. SAD attenuated the decrease in MAP and LSNA response to insulin. Thus, insulin acts to decrease MAP while simultaneously increasing HR, LSNA and RSNA when hypoglycemia is allowed to occur. However, insulin ac...Continue Reading

References

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Citations

Jul 12, 2002·Diabetes/metabolism Research and Reviews·Nahla Salem, Joseph C Dunbar
Dec 24, 2004·Diabetologia·R J HuggettD A S G Mary
May 4, 2010·Regulatory Peptides·Marcos A MayerBelisario E Fernández
Feb 13, 2007·Metabolism: Clinical and Experimental·Martin S MuntzelOnyekwere Onwumere
May 5, 2004·Experimental Physiology·E GrossiniG Vacca
Nov 29, 2005·Metabolism: Clinical and Experimental·Martin S MuntzelOnyekwere Onwumere
Jan 8, 2004·Experimental Biology and Medicine·Natalie Rizk, Joseph C Dunbar
Aug 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S F Morrison

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