The Coding Question

Trends in Cognitive Sciences
C R Gallistel

Abstract

Recent electrophysiological results imply that the duration of the stimulus onset asynchrony in eyeblink conditioning is encoded by a mechanism intrinsic to the cerebellar Purkinje cell. This raises the general question - how is quantitative information (durations, distances, rates, probabilities, amounts, etc.) transmitted by spike trains and encoded into engrams? The usual assumption is that information is transmitted by firing rates. However, rate codes are energetically inefficient and computationally awkward. A combinatorial code is more plausible. If the engram consists of altered synaptic conductances (the usual assumption), then we must ask how numbers may be written to synapses. It is much easier to formulate a coding hypothesis if the engram is realized by a cell-intrinsic molecular mechanism.

Citations

Nov 6, 2018·ELife·Benjamin J De CorteMatthew S Matell
Jul 14, 2019·Hippocampus·Rahul K Rathour, Rishikesh Narayanan
Jan 3, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C R Gallistel
Nov 30, 2019·The Behavioral and Brain Sciences·Charles R Gallistel
Dec 20, 2019·Journal of the Experimental Analysis of Behavior·C R Gallistel, E B Papachristos
Jan 5, 2021·ELife·Samuel J GershmanJeremy Gunawardena
Sep 14, 2018·Entropy·Khalid Sayood
Dec 31, 2020·Cognition·C R Gallistel
Apr 4, 2021·Current Opinion in Neurobiology·Tomás J RyanSiddhartha Sen
May 23, 2021·Biochemical and Biophysical Research Communications·Adam R Gold, David L Glanzman
May 18, 2021·Current Research in Neurobiology·Poonam Mishra, Rishikesh Narayanan
Aug 6, 2021·Frontiers in Microbiology·Jose Carrasco-PujanteIldefonso M De la Fuente

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