The coenzyme nicotinamide adenine dinucleotide (NADH) improves the disability of parkinsonian patients

Journal of Neural Transmission. Parkinson's Disease and Dementia Section
W BirkmayerE Ott

Abstract

The coenzyme nicotinamide adenine dinucleotide (NADH) has been used in an open label trial as novel medication in 34 patients with Parkinson's disease, using an intravenous administration technique. In all patients a beneficial clinical effect was observed. 21 patients (61.7%) showed a very good (better than 30%) improvement of disability, 13 patients (38.3%) a moderate (up to 30%) improvement. Concomitant with the improvement of the disability the urine level of homovanillic acid (HVA) increased significantly in all patients (in some patients by more than a 100%). The daily "on phases" of the patients could be increased from 2 up to 9 hours in the individual patients by NADH administration.

References

Jan 1, 1985·Annual Review of Biochemistry·C A NicholD S Duch
Jan 1, 1986·Journal of Neural Transmission·W Birkmayer, J G Birkmayer
Feb 5, 1981·Clinica Chimica Acta; International Journal of Clinical Chemistry·T NagatsuH Narabayashi

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Citations

Jan 1, 1994·Journal of Neural Transmission. General Section·J LiptrotO Phillipson
Jan 1, 1993·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·K VreckoJ Krainz
Sep 6, 2011·The Journal of Veterinary Medical Science·Jin-Hee SungPhil-Ok Koh
Jun 29, 2006·Journal of Nutritional Science and Vitaminology·Naoko KimuraKatsumi Shibata
Jul 28, 2015·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Jesus Castro-MarreroJose Alegre
Feb 1, 2003·Clinical and Experimental Dermatology·A WoźniackaJ Gebicki
Oct 13, 2004·Phytotherapy Research : PTR·Bala V ManyamTheodore A Hare
Oct 11, 2012·The Journal of Veterinary Medical Science·Phil-Ok Koh
Mar 10, 1999·Brain : a Journal of Neurology·S LoveG K Wilcock
Sep 19, 2020·Pharmaceuticals·Dina RadenkovicEric Verdin

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