The coenzyme nicotinamide adenine dinucleotide (NADH) improves the disability of parkinsonian patients

Journal of Neural Transmission. Parkinson's Disease and Dementia Section
W BirkmayerE Ott


The coenzyme nicotinamide adenine dinucleotide (NADH) has been used in an open label trial as novel medication in 34 patients with Parkinson's disease, using an intravenous administration technique. In all patients a beneficial clinical effect was observed. 21 patients (61.7%) showed a very good (better than 30%) improvement of disability, 13 patients (38.3%) a moderate (up to 30%) improvement. Concomitant with the improvement of the disability the urine level of homovanillic acid (HVA) increased significantly in all patients (in some patients by more than a 100%). The daily "on phases" of the patients could be increased from 2 up to 9 hours in the individual patients by NADH administration.


Jan 1, 1985·Annual Review of Biochemistry·C A NicholD S Duch
Jan 1, 1986·Journal of Neural Transmission·W Birkmayer, J G Birkmayer
Feb 5, 1981·Clinica Chimica Acta; International Journal of Clinical Chemistry·T NagatsuH Narabayashi

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