The cognitive and psychomotor effects of opioid analgesics. II. A randomized controlled trial of single doses of morphine, lorazepam and placebo in healthy subjects

European Journal of Clinical Pharmacology
G W HanksK A Wesnes

Abstract

Twelve subjects (8 male) took part in a randomised double blind four way crossover design study comparing four treatments: (i) morphine sulphate 10 mg, (ii) morphine sulphate 15 mg, (iii) lorazepam 1 mg (positive control) and (iv) placebo. Cognitive function was assessed using choice reaction time, number vigilance, memory scanning, immediate and delayed word recall, word recognition, picture recognition, critical flicker fusion threshold (CFFT) and subjective measures of alertness, calmness and contentment. Lorazepam produced a marked impairment in the tests of attention and memory. CFFT was reduced from 1-4 h but this only reached significance at 4 hours. The subjective measures suggested impaired alertness but this did not reach significance. The effects of morphine were less dramatic; both doses of morphine produced significant impairment at 1 hour on tests of secondary memory retrieval (delayed word recall and picture recognition sensitivity). CFFT was reduced for the whole observation period (6 h) achieving statistical significance at 4 hours. Morphine 15 mg produced a significant improvement in accuracy on the choice reaction time test at the 2, 4 and 6 h assessments. These results show minimal impairment of cognitive an...Continue Reading

Citations

Jul 4, 2001·Drugs·C Ripamonti, E D Dickerson
Dec 14, 2002·The Clinical Journal of Pain·Stanley L ChapmanBarbara A Reed
Apr 10, 2019·Cognitive, Affective & Behavioral Neuroscience·Henk van SteenbergenSiri Leknes
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May 2, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N ChernyUNKNOWN Expert Working Group of the European Association of Palliative Care Network

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