The Cognitive Assessment Interview (CAI): reliability and validity of a brief interview-based measure of cognition.

Schizophrenia Bulletin
Joseph VenturaRobert M Bilder

Abstract

To obtain Food and Drug Administration approval for the treatment of cognitive impairments associated with schizophrenia, a drug will need to demonstrate benefits beyond those that may be documented on objective cognitive tests. Interview-based measures of cognition such as the Cognitive Assessment Interview (CAI) are candidate coprimary outcome measures. Psychiatrically stable schizophrenia outpatients (n=150) were studied using the CAI to obtain information about cognitive functioning from both the patient and an informant. Patients also received objective assessments of neurocognition, functional capacity, functional outcome, and symptoms, at baseline and 1 month later. The CAI had good internal consistency (Cronbach's alpha=.92) and good test-retest reliability (r=.83). The CAI was moderately correlated with objective neurocognitive test scores (r's=-.39 to -.41) and moderately correlated with social functioning (r=-.38), work functioning (r=-.48), and overall functional outcome (r=-.49). The correlations of CAI scores with external validity indicators did not differ significantly by source of information (patient alone ratings were valid). Overall functional outcome correlated more strongly with patient CAI scores (r=-.50)...Continue Reading

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Citations

May 21, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·David NuttBarbara J Sahakian
Apr 20, 2016·Schizophrenia Research·Richard S E KeefePhilip D Harvey
Apr 23, 2014·Cognitive Neuropsychiatry·Ryan P BalzanCherrie Galletly
Jun 9, 2016·European Archives of Psychiatry and Clinical Neuroscience·Ana M Sánchez-TorresManuel J Cuesta
Sep 13, 2016·Schizophrenia Research·Ana M Sánchez-TorresManuel J Cuesta
May 23, 2015·Development and Psychopathology·Matcheri S KeshavanJai L Shah
Sep 17, 2015·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Lucas M MantovaniJoão V Salgado
Aug 21, 2018·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Esra YaziciAtila Erol
Jan 13, 2021·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Mario MajJoseph Ventura
Feb 5, 2021·The Cochrane Database of Systematic Reviews·Matthew T RobertsAnna Zsófia Békefi

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