The cohort of antral follicles measuring 2-6 mm reflects the quantitative status of ovarian reserve as assessed by serum levels of anti-Müllerian hormone and response to controlled ovarian stimulation

Fertility and Sterility
K JayaprakasanNick Raine-Fenning

Abstract

To evaluate the relationship between serum anti-Müllerian hormone (AMH) and antral follicle size, and to ascertain which cohort of antral follicles is most predictive of the response to controlled ovarian stimulation during assisted reproduction treatment (ART). Prospective study. University-based Assisted Conception Unit. One hundred thirteen women undergoing first cycle of ART. Transvaginal 3D-ultrasound assessment and venipuncture in the early-follicular phase of the menstrual cycle. Serum AMH levels, number of mature oocytes retrieved and poor ovarian response. The antral follicle cohorts measuring 2 to 3 mm, >3 to 4 mm, >4 to 5 mm, and >5 to 6 mm were most significantly correlated with AMH (r = .30, .27, .30, and .41, respectively) and the number of mature oocytes retrieved (r = .28, .23, .29, and .34, respectively). Although these follicle cohorts of 2-6 mm were significant predictors of the number of mature oocytes retrieved on regression analysis, their discriminative ability (area under the curve [AUC]: 0.829) for the prediction of poor ovarian response was similar to total counts made using cohorts of 2 to 4 mm, 2 to 5 mm, 2 to 8 mm, and 2 to 10 mm (AUCs: 0.794, 0.812, 0.852, and 0.826, respectively). The number of an...Continue Reading

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Citations

Dec 28, 2010·Journal de gynécologie, obstétrique et biologie de la reproduction·C Ferté-DelbendeD Dewailly
Sep 20, 2011·Human Reproduction·Nick Raine-Fenning
Jan 13, 2012·Human Reproduction·Scott M NelsonAntonio La Marca
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