The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems genetics.

Mammalian Genome : Official Journal of the International Mammalian Genome Society
Elissa J CheslerKenneth F Manly

Abstract

Complex traits and disease comorbidity in humans and in model organisms are the result of naturally occurring polymorphisms that interact with each other and with the environment. To ensure the availability of resources needed to investigate biomolecular networks and systems-level phenotypes underlying complex traits, we have initiated breeding of a new genetic reference population of mice, the Collaborative Cross. This population has been designed to optimally support systems genetics analysis. Its novel and important features include a high level of genetic diversity, a large population size to ensure sufficient power in high-dimensional studies, and high mapping precision through accumulation of independent recombination events. Implementation of the Collaborative Cross has been ongoing at the Oak Ridge National Laboratory (ORNL) since May 2005. Production has been systematically managed using a software-assisted breeding program with fully traceable lineages, performed in a controlled environment. Currently, there are 650 lines in production, and close to 200 lines are now beyond their seventh generation of inbreeding. Retired breeders enter a high-throughput phenotyping protocol and DNA samples are banked for analyses of r...Continue Reading

References

Oct 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·R MottJ Flint
Apr 17, 2002·Mammalian Genome : Official Journal of the International Mammalian Genome Society·David W ThreadgillRobert W Williams
Mar 17, 2004·BMC Bioinformatics·Erich J BakerJay Snoddy
Oct 30, 2004·Nature Genetics·Gary A ChurchillUNKNOWN Complex Trait Consortium
Nov 17, 2004·Genetics·Karl W Broman
Jul 13, 2006·Nature Genetics·William ValdarJonathan Flint
Aug 4, 2007·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Adam RobertsDavid W Threadgill

❮ Previous
Next ❯

Citations

Jul 14, 2010·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Klaus Schughart, UNKNOWN SYSGENET consortium
Aug 1, 2012·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Binnaz Yalcin, Jonathan Flint
Aug 16, 2012·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Gary A ChurchillKaren L Svenson
Mar 23, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Inga J MurawskiIndra R Gupta
Sep 3, 2010·Genetica·Hong Li, Hongwen Deng
Jul 13, 2013·Current Osteoporosis Reports·Cheryl L Ackert-Bicknell, David Karasik
Nov 10, 2012·Theory in Biosciences = Theorie in Den Biowissenschaften·Hong Li
Mar 17, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jason A Bubier, Elissa J Chesler
Jan 1, 2012·BoneKEy Reports·Cheryl L Ackert-Bicknell, Matthew A Hibbs
Jun 15, 2012·The ISME Journal·James H CampbellMircea Podar
May 31, 2011·Nature Genetics·Hyuna YangFernando Pardo-Manuel de Villena
Aug 12, 2009·Nature Methods·Hyuna YangGary A Churchill
Oct 13, 2010·Proceedings of the National Academy of Sciences of the United States of America·Andrew K BensonDaniel Pomp
May 24, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Igor KoturbashIgor P Pogribny
Feb 26, 2011·Biology of Reproduction·Summer G GoodsonDeborah A O'Brien
Dec 17, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·William G Hill
May 17, 2012·Genome Research·David T BurkeAndrzej T Galecki
Apr 7, 2010·Science Translational Medicine·Ming ZhengGary Peltz
Mar 24, 2011·American Journal of Physiology. Endocrinology and Metabolism·Wendy Foulds MathesDaniel Pomp
Aug 4, 2012·American Journal of Physiology. Renal Physiology·Jill ThaiszKeith Dipetrillo
Aug 6, 2010·Veterinary Pathology·J P Sundberg, P N Schofield
Jul 5, 2011·Genome Biology·Louise van der WeydenDarren W Logan
Aug 7, 2012·Stem Cell Research & Therapy·Lauren V SchnabelLisa A Fortier
Feb 22, 2012·PLoS Genetics·Marit Ackermann, Andreas Beyer
Feb 22, 2012·Genetics·Alan B LenarcicWilliam Valdar
Feb 22, 2012·Genetics·Karen L SvensonGary A Churchill
Feb 22, 2012·Genetics·UNKNOWN Collaborative Cross Consortium
Feb 22, 2012·Genetics·David W Threadgill, Gary A Churchill
Mar 31, 2010·Future Virology·Jennifer R TisoncikMichael G Katze
Aug 14, 2010·Pharmacogenomics·Ivan RusynDavid W Threadgill

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.